Tamiflu: analogues at a low price. Tamiflu and Russian flu drugs - doctor's review. Is there an addiction?

Oseltamivir - medicine, belonging to the group of antiviral pharmaceuticals, used to treat an infectious pathology of the respiratory tract caused by the influenza virus.

• What is the composition and form of release of the drug Oseltamivir?

The active ingredient of oseltamivir is oseltamivir phosphate, in the amount of 75 milligrams per capsule or 30 milligrams in powder. Information about excipients medication is missing.

The drug is available in capsules and in the form of a powder created for the preparation of a suspension. Both dosage forms are sold by pharmacies upon presentation of the required prescription.

• What is the effect of Oseltamivir capsules/powder?

The active component of the pharmaceutical product oseltamivir is a prodrug that transforms into an active metabolite - oseltamivir carboxylate, which has a therapeutic effect.

The mechanism of action of the drug Oseltamivir is based on the inhibition of the viral enzyme neuraminidase, which is responsible for the release of collected viral particles from cells and infection of healthy tissues.

The influenza virus infects the cells of the surface layer of the epithelium of the bronchi, after which the collected viral particles must be released, that is, move from the intracellular to the extracellular space, and then penetrate into healthy cells.

Oseltamivir is a drug designed specifically to inhibit the release of the virus and is a treatment for infection caused by influenza A and B viruses.

The use of the drug Oseltamivir immediately after the first signs of malaise can significantly shorten the duration of the disease, as well as reduce the amount of environment pathogens.

The drug does not affect the production of antibodies to influenza viruses. Because of this, it can be used in conjunction with the vaccination procedure. It is important to note that, despite the constant mutation of the causative agent of the disease, the frequency of development of immunity to the pharmaceutical agent Oseltamivir occurs only in 0.32 percent of cases.

When taken orally, oseltamivir phosphate is completely absorbed from the intestine. Biological transformation reactions occur in the liver, with the formation of an active metabolite, the therapeutic concentration of which is recorded in the patient's blood no earlier than 2-3 hours after taking the drug.

Oseltamivir carboxylate is excreted in the urine. The half-life ranges from 6 to 10 hours.

• What are the indications for the use of Oseltamivir?

The use of the antiviral pharmaceutical Oseltamivir, which we consider on this page www.site, is indicated for the treatment and prevention of diseases caused by influenza viruses type A and B.

I remind you that only a qualified specialist can prescribe this remedy. Use without a doctor's approval may not be safe.

• What are the contraindications for Oseltamivir?

The use of the drug Oseltamivir instructions for use prohibits in the following cases:

• Chronic renal failure;

• Age less than a year;

• Pregnancy and lactation.

In addition, the drug is contraindicated in case of individual intolerance.

• What is the use and dosage of Oseltamivir?

You can take Oseltamivir medicine regardless of food, preferably immediately after the first signs of flu-like illness (weakness, fever, pain in the bones, muscles, headache).

Adult patients or adolescents over 12 years of age are prescribed 75 milligrams of the drug, regardless of the chosen dosage form 2 times a day.

Children aged from one year to 7 years should be prescribed only a suspension, and its amount is calculated using special tables that take into account the age and body weight of the patient.

The duration of treatment is usually 5 days. Preventive actions may last longer if the doctor deems it necessary.

• Overdose from oseltamivir

There are no data on the manifestations of an overdose, but, despite this, it is necessary to adhere to the recommended dosages and terms of treatment. It should be remembered that the passion for the amount of drug consumed does not lead to an increase in the therapeutic effect.

• What are oseltamivir side effects?

From the side digestive system: loose stools, soreness and bloating, nausea, vomiting, liver damage, in addition, changes in taste, manifestations of flatulence.

From the side nervous system: weakness, convulsions, disorders of consciousness and behavior, delirium, loss of consciousness, disorientation in time, in addition, delirium, psychomotor agitation, nightmares, headache, and asthenia.

Other side effects: nasal congestion, Stevens-Johnson syndrome, allergic manifestations on the skin, exacerbation of the course of bronchial asthma, bronchospastic phenomena and pneumonia, sinusitis, bronchitis, swollen lymph nodes, and otitis media.

• How to replace Oseltamivir, what analogs to use?

The drug Oseltamivir can be replaced by pharmaceuticals: Tamiflu, Amiflu.

Conclusion

It is very important to take the drug Oseltamivir immediately after the first signs of illness appear. After 2 days from the onset of the disease, the effectiveness of the antiviral agent is significantly reduced.

In addition, it should be remembered that the patient needs to provide balanced diet, fortification, detoxification measures (plentiful drinking), as well as a therapeutic and protective regimen. After that, it will not be superfluous to visit a doctor to confirm the recovery.

Be healthy!

Tatyana, www.site
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ATX code for oseltamivir

J05AH02 (oseltamivir)

You should consult with your doctor before using oseltamivir. These instructions for use are for informational purposes only. For more information, please refer to the manufacturer's annotation.

OSELTAMIVIR: Clinical and pharmacological group

OSELTAMIVIR: Pharmacological action

Antiviral agent. It is a prodrug whose active metabolite (oseltamivir carboxylate) selectively inhibits influenza virus types A and B neuraminidase. Neuraminidase is a glycoprotein that catalyzes the cleavage of the bond between the terminal sialic acid and sugar, thereby contributing to the spread of the virus in the respiratory tract (the release of virions from the infected cell and penetration into the epithelial cells of the respiratory tract, preventing the inactivation of the virus by epithelial mucus). Oseltamivir carboxylate acts outside cells and competitively inhibits viral neuraminidase. It inhibits the growth of the influenza virus in vitro and suppresses the replication of the virus and its pathogenicity in vivo. Reduces the release of influenza A and B viruses from the body.

Does not affect the production of antibodies in response to the introduction of an inactivated influenza vaccine.

The frequency of resistance of clinical isolates of the virus is 2%.

OSELTAMIVIR: Pharmacokinetics

After oral administration, it is almost completely absorbed from the gastrointestinal tract, absorption does not depend on food intake. It has the effect of "first pass" through the liver. Under the influence of intestinal and hepatic esterases, it turns into an active metabolite. 75% of the dose taken orally enters the systemic circulation in the form of an active metabolite, less than 5% - in the form of the parent substance. Plasma concentrations of both the prodrug and the active metabolite are dose proportional.

The average Vd of the active metabolite is 23 liters. Plasma protein binding - 3%.

It is excreted as an active metabolite mainly by the kidneys by glomerular filtration and tubular secretion. T1 / 2 of oseltamivir - 1-3 hours. Oseltamivir carboxylate is not further metabolized and excreted by the kidneys, its T1 / 2 is 6-10 hours. Renal clearance is 18.8 l / h. Excreted through the intestines - less than 20%.

In elderly patients (65-78 years), the concentration of the active metabolite in the equilibrium state is 25-35% higher than in younger patients. In patients with renal insufficiency, the elimination rate of oseltamivir carboxylate is inversely proportional to the CC value.

OSELTAMIVIR: Dosage

Taken orally, regardless of food intake.

When treating, the intake should be started no later than 2 days from the moment the symptoms of the disease develop at a dose of 75 mg 2 times / day for 5 days. Increasing the dose of more than 150 mg / day does not increase the effect.

For the prevention of influenza types A and B in adults - 75 mg 1-2 times / day for 6 weeks. (during the influenza epidemic). The maximum daily dose for adults is 150 mg.

In patients with CC less than 30 ml / min, the dose is reduced to 75 mg 1 time / day for 5 days.

oseltamivir: drug interactions

Drugs that block tubular secretion increase the concentration of the active metabolite by 2-3 times (due to inhibition of the process of active tubular secretion in the kidneys), which does not require dose adjustment.

oseltamivir: Pregnancy and lactation

Use with caution during pregnancy and lactation.

oseltamivir side effects

From the digestive system: nausea, vomiting (usually when taken in high doses, or in the first days of treatment); rarely - diarrhea, abdominal pain.

From the side of the central nervous system: insomnia, dizziness, headache.

From the side respiratory system: nasal congestion, sore throat, cough.

Other: feeling tired, weakness.

OSELTAMIVIR: Indications

Influenza types A and B.

OSELTAMIVIR: Contraindications

Chronic renal failure (CC less than 10 ml / min), liver failure, hypersensitivity to oseltamivir.

oseltamivir: special instructions

Use with caution in children.

In patients with hepatic impairment, the safety and efficacy of oseltamivir have not been established.

There are no data on the safety of using oseltamivir with CC less than 10 ml / min.

During the period of epidemics and colds, which are more common in the cold season, people use all sorts of ways to increase immunity. Some use old and proven recipes for this. traditional medicine. Others resort to medicinal formulations. The opinions of doctors about such prevention are very different.

This article will tell you about what the Zanamivir medication has reviews. You will learn about the trade names of this medicine and will be able to get acquainted with reviews about them.

Products containing zanamivir

In modern pharmacy chains, you can buy a medicine with the trade name "Relenza". It is released in recent times only on doctor's orders. However, unscrupulous sellers can give it away without the corresponding piece of paper.

Many consumers are wondering if there are other products available that contain zanamivir. It is possible to answer this question with full confidence in the negative. Manufacturers of medicines have not yet created an absolute substitute for this drug.

general characteristics

What is the drug "Zanamivir" reviews, you can find out further. To begin with, it is worth giving a description of this drug. As you already know, the trade name of the medication is Relenza. The composition is produced in the form of a powder. It is used exclusively by inhalation. Internal use is unacceptable and contraindicated.

The composition of the drug includes 20 doses. Each contains 5 milligrams of zanamivir. Also among the additional substances can be noted lactose. In the kit for the drug "Zanamivir" instructions are attached necessarily. Also in the package there is an apparatus for inhalation administration of the drug. The method of its use is described in the annotation in sufficient detail.

The cost of the drug

What is the price for the drug with the active ingredient zanamivir? It all depends on where you will purchase the medication. In pharmacy chains that dispense the drug according to the corresponding prescription, the drug costs about 1,300 rubles per pack. In the event that you do not have a prescription from a doctor, pharmacists can, for their own benefit, raise the price to 2,000 rubles and release the goods to you. Repeatedly such situations were registered.

Also, some consumers say that the price of the drug "Zanamivir" is about 3-5 thousand rubles. In this case, the medication is ordered via the Internet. Such manipulation does not require a prescription, but it is completely illegal. Please note that medicinal formulations must be purchased exclusively at the appropriate points that have a license and permission to sell them. Treatment with low-quality medicines purchased in clandestine centers can lead to disastrous consequences.

How to replace the drug?

The active ingredient is different. As you already know, the drug does not have an absolute substitute that would have an identical composition. However, there are products with another active ingredient that work in the same way. The closest medicine to the one described will be the drug "Tamiflu". Zanamivir and oseltamivir are neurominidase inhibitors. They block the release of harmful particles from cells that are already affected by the virus. Note that the active ingredients zanamivir and oseltamivir are unique. They have no analogues with the same composition. The drug "Tamiflu" is available in tablets for internal use and cannot be used by inhalation.

It has the active substance zanamivir analogues and another plan. These drugs include "Interferon", "Isoprinosine", "Rimantadine", "Anaferon", "Derinat", "Isoprinosine" and many others. All of them are less expensive. At the same time, they are available for sale without the corresponding prescriptions from the doctor. The listed medicines can be in the form of tablets, injections, nasal drops and inhalations.

Indications for appointment

As you already know, the drug with the active ingredient zanamivir (Relenza) is sold exclusively by prescription. At the same time, the therapist should prescribe the medication for you. The doctor writes out a form on which the amount of the drug and the duration of the course of use are indicated. Your data (last name and first name) is also required. According to this document, you can freely purchase the specified tool.

The medicine "Zanamivir" ("Relenza") is used as an antiviral and immunomodulatory agent. It is used for treatment and prophylaxis. The annotation states that the powder for inhalation is prescribed for A and B. At the same time, doctors sometimes recommend medication in other situations. The medicine can be used for viral bronchitis, pneumonia and other diseases.

Usage restrictions

About the drug "Zanamivir" instruction says that it should not be used in case of hypersensitivity to the components of the drug. The composition is not prescribed for diabetes and lactase deficiency. This is where the funding limits end.

However, doctors have a slightly different point of view on this matter. They complement the data described by others. About the tool "Zanamivir" reviews of experts report that the drug should not be used by children under the age of 5 years. All due to the fact that the baby will not be able to properly take the drug. Also in the specified means it is impossible to divide the available dose into several parts.

additional information

Can Tamiflu and Zanamivir be used during pregnancy and lactation? As you already know, medicines are contraindicated for young children. So can they harm the baby through the body of his mother? Let's look into this issue.

The annotation states that you should not use the described medicine in the first trimester of pregnancy. In the second and third parts of the term, use is permissible only as directed by a doctor, taking into account all the risks. Physicians hold a different opinion. About the drug "Zanamivir" (trade name - "Relenza") experts report the following. The introduction of the drug in large doses, as well as the use of the Tamiflu analogue, can have an effect on the developing fetus. It is especially dangerous to use drugs in large doses.

Negative reactions: side effects

The active substance zanamivir (trade name of the drug is Relenza) is usually well tolerated by consumers. However, the abstract says that the drug can cause and adverse reactions.

The instructions describe the following cases:

• Allergic reaction, manifested by rash, itching and hives.
• Cough leading to bronchospasm.
• Swelling of the face, larynx, difficulty breathing.

If you are faced with a similar situation, it is recommended to contact a specialist as soon as possible. Further use of this medicine is unacceptable and dangerous.

How to use the medication

From the flu "Zanamivir" is used by inhalation. The medicine has no other way of use. Many patients are interested in whether there are pills with the name "Zanamivir"? This form of release of the drug is not yet available.

Before you start using, you must carefully study the instructions. Also strictly follow all the recommendations that the doctor gave you. If there were none, then follow the annotations.

Take the container for inhalation and examine it carefully. Remove the cap and insert one rotadisk. After that, snap the container and start inhalation. Depending on the purpose of the drug, its dose can vary greatly.

Flu treatment

The antiviral "Zanamivir" is prescribed for adult patients and children over five years of age. In children, the use of the drug should be supervised by adults. The dosage of the drug is two inhalations twice a day. In this case, it is desirable to apply at the same time with an equal interval.

One rotadisk is enough for a day of treatment. The duration of the course is 5 days. With the help of mathematical calculations, you can find out that the packaging of the medicine is enough for the whole course.

Preventive actions

The medicine "Zanamivir" is recommended as a prophylaxis. However, in recent years it has been used less and less. The reason for this was the sale of prescription medication. Experts are trying to prescribe other, more affordable and safe means for the prevention of viral diseases.

As a prevention of influenza and viral infections, the drug is used in adults and children after 10 years. Previously, it is not recommended to use it in the absence of a disease. The instruction for use advises to follow the following algorithm. Two inhalations of 5 milligrams of the active substance are carried out once a day. In order not to get sick upon contact with an infected person, it is necessary to continue such therapy for up to 10 days. One pack of medication is just designed for this period.

Persons with respiratory diseases

The drug "Zanamivir" in rare cases leads to such a side effect as bronchospasm. However, this reaction is not excluded. People who have a history of respiratory diseases are especially susceptible to it. Most often it is asthmatics.

If it is not possible to refuse the described remedy, then it is necessary to have bronchodilator drugs with you for the entire period of treatment. You should not think that if there was no reaction once, then it will not happen later. With the development of bronchospasm, it is necessary to immediately stop the manipulation. As soon as possible, take the appropriate medicine that relieves bronchospasm and expands their lumen. This will help you restore normal breathing. During the procedure, breathe as you do in normal life. No need to take very deep and sharp breaths.

"Zanamivir": patient reviews

What are the opinions about the described medicine among those who used it for treatment or prevention? Many people during epidemics used this remedy. More recently, it could be purchased without a doctor's prescription. Patients say that the drug "Zanamivir" is very effective. The medicine quickly has a positive effect on the body. It enhances immunity and enhances resistance. It should be said right away that the timely started use of the drug after contact with an infected person does not allow a person to get sick.

Also, many patients used the remedy for the treatment of the disease. The drug is prescribed for such serious and dangerous diseases as swine or It is these diseases that often lead to complications and death. Users report that after starting therapy, they feel significantly better. Improvement was observed already on the second or third day. The general course of treatment was five days. In rare cases, the doctor recommended to increase the period of taking the medication.

Patients testify that the drug "Zanamivir" is convenient to use. You can always take a device for inhalation and rotadisks with you. If you cannot go on sick leave and have to go to work, then this will be an invaluable plus.

Expert opinions

Often, patients are interested in the doctor about the drug "Zanamivir", where to buy it? The specialist should always explain to his patient that this medication is sold exclusively by prescription. You should not look for workarounds and purchase the drug at non-specialized points. Doctors say that often there were cases of detection of adverse reactions not considered above from therapy. At the same time, the consumer used an underground method of acquiring a medicine. No one knows what is actually in such a preparation.

Therapists argue that the remedy should not be used for preventive purposes. Currently, there are many alternative means that are recognized as safer and more affordable. You can easily purchase them at a pharmacy and take a prophylactic course of admission. The drug "Zanamivir" is prescribed only when the disease has already been identified.

Some experts report that the drug "Zanamivir" has no proven effectiveness. Doctors say that the effect of the drug is based on the placebo effect. However, the price of the drug and its instructions indicate the opposite. Of course, reviews are very important for specialists and consumers of the drug. However, do not rely solely on them. Doctors advise to study the information about the medicine before using it. But at the same time, be sure to read the instructions for use and take into account the opinion of doctors.

Is there an addiction?

About the drug "Zanamivir" experts say that it is never addictive. Many consumers have a misconception. They believe that viruses can develop resistance to the specified substance. After all, this is exactly what happens with uncontrolled or improper use of antibiotics.

Actually it is not. The specified medicine affects its own immunity, strengthening it. The drug blocks the release of neurominidase. That is why it is called an inhibitor. Means after getting into Airways recognizes the affected cells and prohibits their work. Also, the powder for inhalation containing zanamivir does not allow the virus to penetrate further. The maximum effect of the drug occurs in cases where therapy is carried out in the first two days after the first symptoms of infection appear. Usually it is a headache, a sharp increase in body temperature. In this case, the flu is usually characterized by numbers from 39 degrees and above. Often the patient is not able to eliminate the fever with the usual antipyretic drugs.

Interaction

Often the drug "Zanamivir" is prescribed simultaneously with other drugs. The combination of non-steroidal anti-inflammatory drugs with the indicated medication is most often performed. Such interaction is quite acceptable. There are no negative reactions to treatment. Together, the drugs have a positive effect on the patient's body, relieving inflammation, lowering the temperature and blocking the reproduction of the virus.

It happens that sorbents are prescribed with the indicated medication. They are used to flush out toxins produced by replicating viruses. With this combination of drugs, it is imperative to observe a break. Doctors usually recommend taking one remedy and only after 2-3 hours resorting to using another. Otherwise, it may not work to its full extent.

The appointment of the drug can be carried out simultaneously with antibiotic therapy. However, most antimicrobial formulations are normally combined with the specified drug. But it is worth remembering that with the simultaneous use of medications, it is necessary to consult a doctor. If you have to take any drug and you have been prescribed Zanamivir, tell your doctor. If necessary, the doctor will help you choose the most appropriate regimen.

The medicine should not be used with other antiviral and immunomodulating agents, unless a doctor has given such a recommendation. Such therapy can lead to an overdose of one or another active substance. Any incorrect combination of drugs is fraught with consequences.

Summarize…

You have learned about the drug "Zanamivir". The drug has the trade name "Relenza". It is impossible to replace it with medicines with the same substance. Buying medicine without a prescription from a doctor is difficult and unsafe. Remember that restrictions on the use of medicines are created for a reason. In this way, the state tries to protect a person from improper treatment, which can harm him.

In most cases, this medication has positive reviews. It has practically no contraindications. According to the instructions, the medicine effectively fights viruses different type. However, not all experts are convinced of the effectiveness of the drug. To this day, there are active disputes and research on this subject. To get the right, effective and qualified appointment, you need to consult a doctor. If necessary, the doctor will prescribe a series of studies for you, after which he will recommend one or another remedy. Remember that the flu is an insidious disease. It often leads to a complication that can end lethal outcome. Do not hesitate and use well-known drugs on your own. Good health to you!

The beginning of the first cold weather is always alarming with the appearance of respiratory viral infections. Panic on radio, television, among friends is instantly put aside in the mind, and a person begins to listen to his body in anticipation of a “terrible” virus.

In this article, we will consider cheap analogues of the drug Tamiflu and compare their effectiveness.

Are they really that dangerous viral infections? There is an opinion among doctors working in infectious diseases departments that the greater the fear of the disease, the sooner you will get it. Doctors and nurses have been working in dangerous hospitals for years (for example, tuberculosis, and without wearing a protective mask), and do not get sick with these infections. The percentage of infected personnel in infectious diseases departments is very low.

If you remember Soviet times, then they didn’t blow all the pipes about viruses, and there was no such panic among the population. People went to the skating rinks, rolled in the snow, actively attended New Year's performances and were not so afraid of SARS. Fear is the main culprit of many diseases, even common colds. In addition, the low immunity of our citizens wants to be the best.

Of course, you can not completely dismiss the "trifle" viruses, because. However, there is a large group of people with immunodeficiencies who require supportive antiviral therapy with flu, and sometimes with serious medicines, such as the drug Tamiflu.

It is also necessary to note the inexpediency of prescribing antiviral drugs in cases where the body copes quite independently with the help of only folk methods by producing protective antibodies.

In our article, let's talk about the sensational expensive antiviral drug Tamiflu, which in the epidemic swine flu talked about as almost a panacea. Let's get acquainted with Tamiflu analogues, which are much cheaper and more accessible to the general population.

In order to compile a list of Tamiflu analogues and choose worthy remedies that will not only therapeutically satisfy the patient, but also cost less, we will consider its main parameters.

Release form, price, composition, storage

The drug is available in the form of capsules (75 mg No. 10 each) and powder for suspension (12 mg / 1 ml) - 30 grams of the active substance in a vial. To date, the price of capsules averages 1200 rubles.

The presence of the powder and its price should be checked in a particular pharmacy, because. Recently, Internet search engines do not provide information about this form of the drug. Usually the powder costs 150 rubles more.

The active ingredient in Tamiflu is oseltamivir.. The shelf life of the drug is 5 years.

Indications

The drug is used for the prevention and treatment of influenza (type A and B), as well as parainfluenza. From the age of 12 months, Tamiflu is prescribed to children. In practice, the remedy is used earlier, starting from six months.

Contraindications

It is not recommended to use Tamiflu in severe renal pathologies and not susceptibility to the main, as well as auxiliary composition. A relative contraindication is pregnancy and lactation, but at the discretion of the doctor, Tamiflu can be used during this period.

Adverse reactions

Sometimes the following "side effects" can be observed:

• dizziness;
• nausea (sometimes vomiting);
• epigastric pain;
• indigestion (diarrhea, or a feeling of urging to pass a stool);
• weakness;
• hallucinatory manifestations;
• sleep disturbance;
• allergic reactions;
• cough;
• laryngitis;
• conjunctivitis;
• other.

Dosage

When the first symptoms of influenza appear, the drug should be applied no later than 48 hours.

For babies, a suspension is used, because the child cannot swallow the capsules. In the absence of a commercially available powder for the preparation of a suspension, you can use the contents of the capsules. The calculation of the required dose is carried out by the pediatrician, taking into account the age and weight of the child.

Patients weighing at least 40 kg take capsules twice a day (morning and evening). After 12 years, it is also recommended to take Tamiflu twice for 5 days, i.e. a blister of 10 tablets is used.

In order to prevent the dosage should be as follows:

• patients weighing more than 40 kg, as well as children over 12 years old, Tamiflu is prescribed for 10 days, 1 capsule per day;
• For babies, prophylactic doses are determined only by a pediatrician.

After reading the instructions, it is easy to see that Tamiflu is used only for influenza, has a high price and a large list of potential adverse reactions. On the positive side, influenza can be treated in young children.

Of course, not all patients are ready to pay 1,200 rubles for 10 Tamiflu tablets, yet “our patient” is always looking for an analogue cheaper, so that the price is not so affordable. Are there any such analogues? Let's try to figure it out.

Dr. Komarovsky about Tamiflu

List of cheap analogues

Almost all antivirals are cheaper than Tamiflu, so the list of analogues will be long. But we will not list information from pharmacological reference books, but will present a list of drugs that, according to statistics, are most often used for influenza, as an alternative to Tamiflu:

• ingavirin 60 mg (7 capsules) - 370 rubles;
• arbidol 100 mg (10 caps.) - 230 rubles;
• relenza 20 mg (5 rotadisks) - 1100 rubles;
• Kagocel 12 mg (12 tablets) - 270 rubles;
• amixin 60 mg (10 tab.) - 600 rubles;
• cycloferon 150 mg (10 tab.) - 190 rubles;
• anaferon (20 tab.) - 230 rubles.

Tamiflu or Ingavirin - which is better?

The cheap Russian analogue Ingavirin is considered an excellent substitute for Tamiflu, and not only in terms of price, but also in terms of therapeutic effect. Therefore, high sales of this drug have recently been noticed.

Ingavirin has wider indications than Tamiflu. It is prescribed for acute respiratory viral infections, adenoviruses and other respiratory infections. Tamiflu is only used for the flu.

Unlike Tamiflu, Ingavirin suppresses not only viruses, but relieves inflammation, eliminates toxins, activates the production of its own interferon, and eliminates catarrhal phenomena. The preparations under consideration have absolutely different composition, so they are not structural analogues.

Lack of Ingavirin - the drug is used only from the age of 18(dosage 90 mg) and from 7 years (60 mg). Tamiflu is recommended for use from the age of 12 months. The advantage of Ingavirin is that it does not have a toxic effect, like Tamiflu.

According to clinical trials there is evidence of a more pronounced antiviral action Ingavirin compared with Tamiflu.

The price of Ingavirin is 3.5 times cheaper.

Tamiflu and Relenza are used only for influenza, and they are almost the same price. Relenza is a little cheaper, about 100 rubles. The active ingredient in Relenza is zanamivir, while in Theraflu it is oseltamivir. The active substances of these drugs inhibit neuraminidase (a specific enzyme of viruses).

Funds differ in the form of issue. Relenza is for inhaled use only in the treatment of influenza. The procedures are carried out using a special inhaler. Thanks to this method of application, the medicinal spray reaches the lower parts of the respiratory system.

Plasma concentrations of oseltamivir are higher than those of zanamivir. Therefore, using the release, it is possible to avoid negative impact on the gastrointestinal tract and central nervous system. A negative point when inhaling relenza is the possibility of bronchospasm, swelling of the larynx, difficulty breathing, especially in people prone to allergies.

Unlike Tamiflu, Relenza is prescribed only from the age of 5 years.

When choosing these funds, patients are interested in what is better to choose: relenza or Tamiflu, especially since they have almost the same price. AT this case taking into account the general symptoms of the patient, and the selection of the drug will be carried out. If bronchopulmonary symptoms prevail, it is better to purchase relenza.

Tamiflu or Kagocel, which do you prefer? It’s worth noting right away - with flu with pronounced symptoms: fever, aches, intoxication, pain in the joints and muscles, loss of appetite, Tamiflu will be more effective. Kagocel is clearly inferior in its antiviral effect in case of influenza infection.

The release form of the drugs is different, Kagocel is available only in tablets. Unlike Tamiflu, Kagocel is an interferon inducer and also has antibacterial and radioprotective effects.

In pediatrics, Kagocel is used from the age of three, although the drug is not toxic. In addition to influenza, it is effective in the treatment of chlamydia (in a complex scheme), herpes, SARS, and other viral infections.

The selection of any antiviral drugs is carried out only by a doctor, do not forget about it!

Unlike Tamiflu, amixin is used only from the age of seven, and its price is two times cheaper. The scope of use is not limited to influenza. Amiksin is a frequently prescribed remedy for respiratory infections, which has not only antiviral activity, but also a pronounced immunomodulatory property.

Amiksin shows effectiveness in herpes, cytomegalovirus, viral hepatitis, and other pathologies of viral origin. Amiksin, compared with Tamiflu, does not have toxicity, and side effects are so rare that they are practically reduced to zero. Most often, this is an individual intolerance to the composition of the drug.

Amiksin or Tamiflu - which is better? It is impossible to answer unambiguously. It is necessary to consider a specific clinical case, taking into account the symptoms, age, allergic history and immune status of the patient. Only the complex of these information about the patient will help to choose one of these means.

Despite its inexpensive cost, the drug shows high efficiency in many diseases: influenza, SARS, viral hepatitis, HIV, neuroinfections, and others. This effect is due to a combination of three properties of the drug: antiviral, anti-inflammatory and immunomodulating. A successful combination of active ingredients allows you to quickly eliminate the symptoms of influenza and SARS.

Unlike Tamiflu, the drug has only a tablet form and is used in children only from 4 years of age. Cycloferon has no side effects, with the exception of possible allergic reactions. Therefore, long-term courses of taking this drug are safe, which allows treatment in patients with immunodeficiencies, such as HIV infection.

The price of cycloferon is 5 times less, it is not surprising that patients quite often prefer it to Tamiflu.

This drug belongs to homeopathy, the composition of which includes affinity-purified antibodies to human interferon gamma. Anaferon has two tablet forms: adult and children. The second form allows you to use the remedy from the age of one month. For the youngest patients, the tablets are powdered and dissolved in water according to the prescribed dose.

There are more indications for the use of Anaferon than for Tamiflu. They include: herpes virus, infectious mononucleosis, SARS, immunodeficiencies, bacterial lesions, and other pathologies. Homeopathy acts gradually, forcing the body to “get out” on its own due to its own reserves and self-healing. In the future, this reduces the number of recurrences of respiratory infections.

Anaferon activates antiviral immunity, and acts more slowly than Tamiflu for influenza. With aggressive SARS and influenza, Anaferon is more suitable as a complex therapy for these diseases than separately, but with good immunity in a patient, even with influenza infection, it can also be used as monotherapy.

It can be concluded that Tamiflu is antiviral agent, and anaferon is an activator of antiviral immunity.

The price of Anaferon is much lower than that of Tamiflu, about 5 times.

Issue on the effectiveness of Tamiflu

Conclusion

The selection of analogues is not always a simple matter. Of course, if the replacement is made only taking into account the price, then there is no problem, we compared the cost, and took the drug cheaper. But such an approach, to put it mildly, is philistine, and has nothing in common with professionalism. Well, if the drug is suitable and has the expected effect of the treatment.

Unfortunately, pharmacy workers often, seeing the desire of the buyer to buy a cheap antiviral drug, offer funds, taking into account only the price, but not the patient's complaints. Although in principle they are not obliged to advise patients at all.

It is a pity when patients in the first days of influenza and SARS do not receive professional help, and then Tamiflu or its analogues bought at a high price will not bring the expected result by at least 50%. Money is wasted and disappointment about the drug and the whole course of treatment remains.

Remember, antiviral agents are selected exclusively by a doctor., because the doctor always adjusts the dosage according to the instructions, according to the ongoing flu or SARS. Sometimes the course of treatment lasts only three days, and in some cases, anti-influenza therapy is recommended to be extended longer than even indicated in the instructions. Be healthy!

• Dioxidin from the common cold - how to take, side effects, reviews

Why is Oseltamivir prescribed? Instructions for use, analogues, indications and contraindications of this medication will be described a little further. We will also tell you about the form in which the said medication can be purchased, what properties it has, whether it has side effects, etc.

Form, composition, description of the medicinal product

This drug goes on sale in the form of white-yellow capsules. Oseltamivir is a prodrug. When ingested, it undergoes hydrolysis and is converted into the active substance - oseltamivir carboxylate.

In addition to capsules, this medication is also available in the form of a light powder for the preparation of an oral suspension.

Features of the drug

How does the drug "Oseltamivir" work? Instructions for use states that the therapeutic effect of this drug is based on the suppression of the activity of enzymes that are located on the surface of the influenza virus virion.

After the drug enters the human body, its main component is transformed into an active metabolite. Thus, oseltamivir carboxylate selectively inhibits neurominidase. As a result of such exposure, the process of reproduction of viral cells stops.

According to experts, this medication should be taken within 35 hours after the first signs of flu appear. Only in this way can the duration of the disease be reduced by 30%, and the likelihood of complications and the severity of symptoms by 40%.

Pharmacokinetics of the drug

Is the drug "Oseltamivir" absorbed? The instructions for use indicate that about 90% of oseltamivir phosphate is absorbed into gastrointestinal tract. The active substance is converted to oseltamivir carboxylate, and then enters the systemic circulation.

About 3% of the active ingredient binds to plasma proteins. Its bioavailability is approximately 76-85% and its half-life is 120 minutes.

From the human body, oseltamivir carboxylate is excreted through the kidneys (about 80%) and intestines (20%). The half-life of this drug is 6-10 hours.

Indications for use

Why is the drug "Oseltamivir" prescribed (pharmaceutical group - antiviral agents)? According to the attached instructions, this medication is used to treat influenza A and B. It is also often used to prevent these viral diseases.

Contraindications for use

Does Oseltamivir have contraindications (the description of the drug was presented above)? According to the instructions, this medication should not be taken when:

It should also be noted that this medication is not recommended for children under 13 years of age, since experts have not determined the safety and effectiveness of using Oseltamivir for the prevention and treatment of influenza.

The drug "Oseltamivir": instructions for use

Vidal (Directory of Medicines) contains full information about how and in what dosages it is necessary to take the drug in question. However, it should be noted that only the attending physician should prescribe this medication. After all, only an experienced specialist will be able to choose the right treatment regimen that will quickly and effectively eliminate all the unpleasant symptoms of a viral disease.

So what dosage is prescribed "Oseltamivir"? Instructions for use indicate that this drug should be used no later than 2 days from the moment the first signs of influenza appear.

For children over 13 years of age and adults, the drug is prescribed in an amount of 75 mg twice a day for 5 days. It should be immediately noted that an increase in the dosage of the drug (for example, up to 150 mg per day) does not lead to an increase in the therapeutic effect.

If the drug must be prescribed to children aged 1-12 years, then the dosage is selected depending on the body weight of the child.

For the prevention of influenza, adults and children over 13 years of age are prescribed 75 mg 1 time per day for 6 weeks (for example, during an epidemic).

In patients with Cl creatinine less than 30 ml per minute, dosage adjustment is required (75 mg once a day for 5 days).

Side effects after taking the medication

What adverse reactions occur after taking the drug "Oseltamivir"? Instructions for use states that the most common adverse reactions are nausea and vomiting. In most cases, these effects are mild or moderate and usually occur in the first days of treatment.

It should also be noted that some patients while taking the drug in question develop bronchitis, vertigo, insomnia, unstable angina, anemia, pneumonia, fracture of the humerus, peritonsillar abscess and fever.

Very rarely, people taking oseltamivir experience abdominal pain, hearing loss, epistaxis, and conjunctivitis. In most cases, such reactions occur once and disappear on their own, despite continued therapy. Such phenomena do not require discontinuation of the drug.

After appointment antiviral drug children and adolescents also show undesirable effects. These include rashes, swelling of the tongue or face, arrhythmias, confusion, seizures, and worsening diabetes.

drug interaction

Information obtained in the course of pharmacokinetic and pharmacological studies states that the development of clinically significant drug interactions this drug is unlikely.

The instructions attached to the drug say that the simultaneous use of this medication with probenecid leads to an increase in the AUC of the active metabolite by 2 times. But dose adjustment is not required.

Cases of overdose

What signs are observed in patients when taking high doses of the drug "Oseltamivir"? Reviews and instructions say that so far there have been no such cases. However, single doses of antiviral medication may cause vomiting or nausea.

To eliminate such symptoms, symptomatic therapy is carried out.

What should a patient know before taking Oseltamivir? Instructions for use (children and adults may experience different side effects) indicates that this drug is not suitable for annual vaccination. It does not prevent the development of complications that may occur during viral disease as well as bacterial infection.

Drug analogues

"Oseltamivir" - medicinal product, which is intended for the treatment and prevention of influenza. It is an antiviral agent that belongs to the inhibitors of neuraminidase. This medication is widely known under the brand name "Tamiflu". It has no structural analogues. The closest, but slightly inferior in effectiveness, are the following substitute drugs: Relenz, Arbidol, Flustol, Kagocel and others.