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Description of the dosage form
Tablets: from white with a yellowish tinge to yellow color with an orange tint, flat-cylindrical, with a chamfer, with a risk - on one side and the inscription "PO" - on the other. The presence of barely noticeable inclusions of a more intense color is allowed.
Lyophilisate for solution for injection and topical application: porous mass from white with a yellowish tinge to yellow. The drug is hygroscopic and photosensitive.
Suppositories: torpedo-shaped, light yellow in color with a slight specific smell of cocoa butter.
special instructions
In case of pain at the injection site, the drug is dissolved in 1 ml of a 0.25% procaine solution if the patient does not have an increased individual sensitivity to procaine.
The solution for sublingual and intranasal use can be stored in the refrigerator for up to 7 days. Before use, the pipette with the solution must be warmed to room temperature (20-25 °C).
Suppositories. Do not exceed the indicated doses and duration of treatment without consulting your doctor.
Composition and form of release
Composition and form of release
in a blister pack 10 pcs.; in a pack of cardboard 1 or 2 packs.
in ampoules or bottles of colorless or dark neutral glass of 4.5 mg; in a pack of cardboard 5 ampoules or vials; or in a blister pack 5 ampoules or vials; in a pack of cardboard 1 pack; or in a cardboard pack of 5 ampoules or vials complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).
in ampoules or vials of colorless or dark neutral glass of 9 mg; in a pack of cardboard 5 ampoules or vials; or in a blister pack 5 ampoules or vials; in a pack of cardboard 1 pack; or in a cardboard pack of 5 ampoules or vials complete with a solvent in ampoules (5 ampoules of water for injection or 5 ampoules of 0.9% isotonic sodium chloride solution).
in a blister pack 5 pcs.; in a pack of cardboard 2 packs.
Pharmacological properties
Pharmacokinetics
Polyoxidonium ® has a high bioavailability (89%); the time to reach Cmax in the blood after i / m administration is 40 minutes; quickly distributed to all organs and tissues. The half-life in the body with intravenous administration is 25 minutes, T 1/2 (slow phase) is 25.4 hours, with intramuscular administration is 36.2 hours. In the body, the drug is hydrolyzed to oligomers, which are excreted mainly by the kidneys.
For suppositories: bioavailability - high (up to 70%); C max in the blood is achieved 1 hour after administration; T 1/2 of the fast phase is about 30 minutes, the slow phase is 36.2 hours.
Pharmacodynamics
Increases the body's resistance to bacterial, fungal and viral infections. The basis of the mechanism of immunomodulatory action of Polyoxidonium ® is a direct effect on phagocytic cells and natural killers, as well as stimulation of antibody production.
Restores immune responses in secondary immunodeficiency states caused by infections, injuries, burns, malignant neoplasms, complications after surgical operations, the use of chemotherapeutic agents, incl. cytostatics, steroid hormones.
With sublingual application, Polyoxidonium activates lymphoid cells located in the bronchi, nasal cavity, Eustachian tubes, thereby increasing the resistance of these organs to infectious agents.
When administered orally, Polyoxidonium ® activates lymphoid cells located in the intestine, namely B-cells that produce secretory IgA.
The consequence of this is an increase in the resistance of the gastrointestinal tract and respiratory tract to infectious agents. In addition, when administered orally, Polyoxidonium ® activates tissue macrophages, which contributes to faster elimination of the pathogen from the body in the presence of an infection focus.
Along with the immunomodulating action, Polyoxidonium ® has a pronounced detoxifying and antioxidant activity, which are determined by the structure and high-molecular nature of the drug. Increases resistance of cell membranes to cytotoxic action medicines and chemical substances reduces their toxicity.
The use of Polyoxidonium ® in complex therapy improves the effectiveness and reduces the duration of treatment, significantly reduces the use of antibiotics, bronchodilators, corticosteroids, and prolongs the period of remission.
The drug is well tolerated, does not have mitogenic activity, antigenic properties; does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect.
Indications
Indications
Tablets.
In adults and adolescents over 12 years of age in complex therapy:
acute and chronic inflammatory recurrent bacterial, viral and fungal infections of the oral cavity, paranasal sinuses, upper respiratory tract, inner and middle ear.
In a group of immunocompromised adolescents and adults in the form of monotherapy (sublingually):
prevention of influenza and other acute respiratory infections in the pre-epidemic period.
Lyophilisate for solution for injection and topical application. Correction of immune deficiency in adults and children.
In adults in complex therapy(6 mg):
chronic recurrent inflammatory diseases of any etiology, not amenable to standard therapy, both in the acute stage and in remission;
rheumatoid arthritis, long-term treated with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
tuberculosis;
acute and chronic allergic diseases (including hay fever, bronchial asthma, atopic dermatitis), complicated by chronic recurrent bacterial and viral infection;
during and after chemotherapy and radiation therapy of tumors; to reduce the nephro- and hepatotoxic effects of drugs;
to activate regenerative processes (fractures, burns, trophic ulcers).
As monotherapy
for the prevention of postoperative infectious complications;
correction of secondary immunodeficiencies arising from aging or exposure adverse factors;
prevention of influenza and acute respiratory infections.
In children from 6 months of age complex therapy(3 mg):
acute and chronic inflammatory diseases caused by pathogens of bacterial, viral, fungal infections (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, SARS);
acute allergic and toxic-allergic conditions;
bronchial asthma complicated by chronic infections of the respiratory tract;
atopic dermatitis complicated by purulent infection;
intestinal dysbacteriosis (in combination with specific therapy);
for the rehabilitation of frequently and long-term ill children;
Suppositories:
In adults and children over 6 years of age complex therapy(for the correction of immune deficiency):
in chronic recurrent inflammatory diseases of any etiology that are not amenable to standard therapy, both in the acute stage and in remission;
acute and chronic viral and bacterial infections (including urethritis, cystitis, chronic pyelonephritis in the latent stage and in the acute stage, prostatitis, chronic salpingo-oophoritis, endometritis, colpitis; diseases caused by papillomavirus; cervical ectopia; dysplasia and leukoplakia) ;
various forms of tuberculosis;
allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis) complicated by recurrent bacterial and viral infection;
rheumatoid arthritis, long-term treated with immunosuppressants; or complicated by the occurrence of acute respiratory infections or acute respiratory viral infections;
to activate regenerative processes (fractures, burns, trophic ulcers);
for the rehabilitation of frequently and long-term ill people (more than 4–5 times a year)
during and after chemotherapy and radiation therapy of tumors;
to reduce the nephro- and hepatotoxic effects of drugs.
As monotherapy :
with seasonal prevention of exacerbations of chronic foci of infections, incl. in the elderly;
for the prevention of recurrent herpetic infection;
for the correction of secondary immunodeficiencies arising from aging or exposure to adverse factors;
for the prevention of influenza and acute respiratory infections.
Contraindications
Contraindications
Increased individual sensitivity, pregnancy (no clinical experience).
Carefully- acute renal failure.
Additionally for lyophilizate for solution for injection and topical application: carefully- children's age up to 6 months (clinical experience is limited).
Dosage and administration
Dosage and administration
Tablets. sublingual and inside, 20-30 minutes before meals. Adults at doses of 12 or 24 mg, adolescents at a dose of 12 mg daily 1, 2 or 3 times a day, depending on the diagnosis and severity of the disease.
sublingual at a dose of 12 mg:
At inflammatory processes oral cavity(bacterial, viral and fungal nature) - 2 times a day at intervals of 12 hours, for 10-14 days. In severe forms of herpetic and fungal infections of the oral cavity - 3 times a day at intervals of 8 hours for 15 days.
For chronic diseases of the paranasal paranasal sinuses and chronic otitis- 2 times a day at intervals of 12 hours, for 5-10 days.
For chronic tonsillitis- 3 times a day at intervals of 8 hours for 10-15 days.
For chronic diseases of the upper respiratory tract- adults at a dose of 24 mg 2 times a day, adolescents at a dose of 12 mg 2 times a day, at intervals of 12 hours, for 10-14 days.
For the prevention of influenza and acute respiratory infections— for immunocompromised individuals suffering from acute respiratory infections more than 4 times a year, Polyoxidonium ® is recommended in the pre-epidemic period for adults at a dose of 24 mg, for adolescents at a dose of 12 mg sublingually 2 times a day for 10-15 days.
inside. In chronic diseases of the upper respiratory tract - adults at a dose of 24 mg 2 times a day, adolescents at a dose of 12 mg 2 times a day, with an interval of 12 hours, for 10-14 days.
Lyophilisate for solution for injection and topical application. V/m, i/v, intranasally, sublingually. Methods of application are chosen by the doctor depending on the diagnosis, the severity of the disease, the age of the patient.
V/m or i/v(drip). The drug is prescribed for adults in doses of 6-12 mg 1 time per day, daily, or every other day, or 1-2 times a week, depending on the diagnosis and severity of the disease.
For i / m administration, the contents of the ampoule or vial are dissolved in 1.5-2 ml of 0.9% sodium chloride solution or water for injection. For intravenous (drip) administration, the drug is dissolved in 3 ml of 0.9% sodium chloride solution, Hemodez, Reopoliglyukin or 5% dextrose solution, then sterilely transferred into a vial with the indicated solutions with a volume of 200-400 ml.
The prepared solution for parenteral administration is not subject to storage.
Parenterally:
6 mg daily for 3 days, then every other day with a total course of 5-10 injections.
6 mg every other day 5 injections, then 2 times a week with a course of at least 10 injections.
For tuberculosis: 6 mg 2 times a week with a course of 10-20 injections.
For rheumatoid arthritis: 6 mg every other day - 5 injections, then 2 times a week with a course of at least 10 injections.
In patients with acute and chronic urogenital diseases: 6 mg every other day with a course of 10 injections in combination with chemotherapy drugs.
For chronic recurrent herpes: 6 mg every other day in a course of 10 injections in combination with antiviral drugs, interferons and inducers of interferon synthesis.
For the treatment of complicated forms of allergic diseases: 6 mg, a course of 5 injections - the first 2 injections daily, then every other day. In acute allergic and toxic-allergic conditions, administer 6-12 mg intravenously in combination with antiallergic drugs.
In cancer patients:
Before and during chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents, 6-12 mg every other day with a course of at least 10 injections;
To prevent the immunosuppressive effect of the tumor, to correct immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor, long-term use of Polyoxidonium ® (from 2-3 months to 1 year), 6 mg 1-2 times a week, is indicated.
In patients with acute renal failure appoint no more than 2 times a week.
intranasally is prescribed for the treatment of acute and chronic infections of the ENT organs, to enhance the regenerative processes of the mucous membranes, for the prevention of complications and relapses of diseases, for the prevention of influenza and acute respiratory infections: 1-3 drops in each nasal passage after 2-3 hours (at least 3 4 times a day) for 5-10 days. A dose of 6 mg is dissolved in 1 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature (20 drops) and the solution is used within a day.
Children. Methods of application are chosen by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.
Parenterally (i/m or i/v drip) at a dose of 0.1-0.15 mg / kg daily, every other day or 2 times a week with a course of 5-10 injections.
For i / m administration, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip, the drug is dissolved in 1.5-2 ml of a sterile 0.9% solution of sodium chloride, Polyglukin, Hemodez or 5% dextrose solution, sterilely transferred into a vial with the indicated solutions with a volume of 150-250 ml.
In acute inflammatory diseases: 0.1 mg / kg every other day with a course of 5-7 injections.
For chronic inflammatory diseases: 0.15 mg/kg 2 times a week for up to 10 injections.
In acute allergic and toxic-allergic conditions: IV drip at a dose of 0.15 mg/kg in combination with antiallergic drugs.
For the treatment of complicated forms of allergic diseases in combination with basic therapy: i / m at 0.1 mg / kg course of 5 injections with an interval of 1-2 days.
Intranasally: daily at a daily dose of 0.15 mg/kg for 5-10 days.
Intranasally, the drug is administered 1-3 drops in one nasal passage after 2-3 hours (at least 3-4 times a day).
To prepare a solution for intranasal and sublingual use, a 3 mg dose is dissolved in 1 ml (20 drops), a 6 mg dose in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. 1 drop of the prepared solution (50 µl) contains 0.15 mg of Polyoxidonium ®, which is prescribed per 1 kg of the child's body weight.
Calculation of the daily dose for children
Sublingual: for all indications - daily at a daily dose of 0.15 mg / kg for 10 days, for the treatment of intestinal dysbacteriosis for 10-20 days.
Suppositories. Rectally(after bowel cleansing) intravaginally. The method of administration and dosage regimen is determined by the doctor depending on the diagnosis, severity and severity of the process.
Polyoxidonium ® can be applied daily, every other day or 2 times a week.
Polyoxidonium ® suppositories 12 mg are used rectally and intravaginally in adults.
Rectally: 1 supp 1 time per day (after bowel cleansing).
Intravaginally: the suppository is inserted into the vagina in the "lying" position 1 time per day, at night.
Polyoxidonium ® suppositories 6 mg are used: in adults - rectally and intravaginally as a maintenance dose; in children over 6 years old - rectally at the rate of 0.20-0.25 mg / kg.
Standard scheme application of Polyoxidonium ® - 1 supp. 6 or 12 mg for 3 days, and then - 1 time in 2 days with a course of 10-15 supp. If necessary, the course of treatment is repeated after 3-4 months.
Patients with chronic immune deficiency (including those with oncological diseases) are shown long-term (from 2-3 months to 1 year) maintenance therapy with Polyoxidonium ® : adults - 6-12 mg, children over 6 years old - 6 mg 2 times a week .
As part of complex therapy. Rectally.
In chronic recurrent inflammatory diseases in the acute stage- according to the standard scheme, in remission - 1 supp. 12 mg in 1-2 days, with a general course of 10-15 supp.
In acute infectious processes- 1 supp. daily, the general course is 10 injections.
With tuberculosis- according to the standard scheme. The course of treatment is at least 15 supp., then it is possible to use maintenance therapy for 2 supp. per week for 2-3 months.
In allergic diseases complicated by recurrent bacterial and viral infections,- according to the standard scheme.
During and after chemotherapy and radiation therapy of tumors- 1 supp. daily for 2-3 days before the start of therapy. Further, the frequency of administration of suppositories is determined by the doctor, depending on the nature and duration of basic therapy.
To reduce the nephro- and hepatotoxic effects of drugs. The duration and scheme of prescribing suppositories is determined by the doctor, depending on the basic therapy.
For the correction of secondary immunodeficiencies arising from aging- 12 mg 2 times a week. Course - 10 supp.
For the rehabilitation of often (more than 4-5 times a year) and long-term ill persons- 1 supp. in one day. The course of treatment is 10 supp.
In rheumatoid arthritis treated long-term with immunosuppressants,- 1 supp. every other day with a general course of 15 injections; with complicated acute respiratory infections or acute respiratory viral infections during rheumatoid arthritis- according to the standard scheme.
To activate regenerative processes (fractures, burns, trophic ulcers)- daily 1 supp. The course of treatment is 10-15 supp.
As monotherapy:
For seasonal prevention of exacerbations of chronic foci of infections, for the prevention of recurrent herpes infection- every other day for adults - 6-12 mg, for children - 6 mg. Course - 10 supp.
For the correction of secondary immunodeficiencies, the prevention of influenza and acute respiratory infections- according to the standard scheme.
For gynecological diseases (rectally or intravaginally)- 1 supp. (12 mg) for 3 days, and then - 1 time in 2-3 days. The course of treatment is 10-15 supp.
Use during pregnancy and lactation
Contraindicated in pregnancy.
Interaction
Compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, corticosteroids, cytostatics and beta-agonists.
Side effects
Side effects
Pain at the injection site is possible when administered intramuscularly (lyophilizate for solution for injection).
The drug Polyoxidonium belongs to the group of immunostimulating agents of a new generation. It was invented by Russian scientists, has been used for about twenty years, and today the medicine has no analogues. Release form: tablets, suppositories, powder for injections. We will find out how and why Polyoxidonium tablets are used.
Polyoxidonium - tablet composition
Considered dosage form The drug Polyoxidonium, the composition of which is represented by one active and several auxiliary ingredients, is a yellowish tablet with a risk, without a shell. The main component is azoximer bromide, and in one tablet it is contained in an amount of 12 g. This is a synthetic water-soluble polymer compound with unique properties that have been confirmed by numerous studies. Auxiliary connections:
- starch;
- mannitol;
- polyvinylpyrrolidone;
- betacarotene;
- stearic acid;
- lactose monohydrate.
Polyoxidonium - indications for use
The main purpose of the drug is to increase the body's resistance to local and generalized infections of various nature and localization. The mechanism of its action is associated with the activation of the ability of leukocyte cells to phagocytize (destroy) pathogens, stimulation of the production of the most important substances for the immune system - cytokines, antibodies, lymphoid cells. At the same time, the influence on the synthesis of cytokines by means of the drug occurs only at initially low and medium rates, i.e. Polyoxidonium acts selectively.
As a result of taking the medicine, the entire immune system is activated, actively counteracting viral, bacterial and fungal infectious agents. In addition, Poliokidonium in tablets has the following effects:
- antioxidant action - binding of free radicals that damage cell membranes (including cells of the immune system);
- detoxification effect - improving the binding and excretion of toxic substances, salts of heavy metals from the body;
- membrane stabilizing effect - protection and restoration of the structure and properties of cell membranes;
- hepatoprotective properties - limiting the load on the liver due to the binding of toxins.
Thanks to this a wide range actions in medical practice Polyoxidonium, the indications of which are considered, is recommended in such cases:
- chronic and acute pathologies of an infectious and inflammatory nature affecting the oral cavity, pharynx, tonsils, nasal appendages, auditory organs (tonsillitis, otitis media, sinusitis, etc.);
- diseases of the upper and lower respiratory tract (bronchitis, tracheitis, pleurisy tuberculosis);
- allergic diseases complicated by infectious processes (including bronchial asthma, hay fever);
- recurrent;
- recurrent furunculosis;
- infectious diseases of the genitourinary tract (pyelonephritis, cystitis, salpingo-oophoritis, colpitis, endometritis, endocervicosis, etc.);
- prevention of post-infections in surgical patients;
- seasonal prevention of influenza and other acute respiratory viral diseases;
- congenital and secondary immunodeficiencies associated with aging or exposure to adverse factors.
The drug is used both for prophylactic purposes and as part of complex or monotherapy for pathologies. It should be noted that Polyoxidonium tablets are not used in oncology, but an injectable form of the drug is used to increase resistance to infections and detoxification after chemotherapy. At the same time, the course and forecast of the oncological disease this medicine has no effect.
How to take Polyoxidonium tablets?
After determining the diagnosis, severity and severity of the pathological process, the doctor can recommend how to take Polyoxidonium in each case. The pills are taken in two ways:
- orally - by swallowing whole with drinking water;
- sublingual - dissolution in the oral cavity under the tongue.
Can I take Polyoxidonium when I'm sick?
Polyoxidonium, the use of which is justified in many infectious diseases, can be used both in the period of remission of chronic diseases and in the acute phase. Due to the use of this medicine, the degree of damage to healthy tissues is significantly reduced, toxic effects are reduced, and the duration of the disease is shortened. It is most effective to prescribe it simultaneously with etiotropic drugs that eliminate causative pathological factors.
Can Polyoxidonium be taken with antibiotics?
Considering how to take Polyoxidonium correctly, many are interested in the possibility of taking these tablets in parallel with antibiotic drugs. The instructions for this medication noted that it is compatible with many drugs, including antibiotics. Polyoxidonium can be prescribed both after and before taking antibacterial agents, which helps to achieve more effective elimination of the pathogen from the body.
In addition, Polyoxidonium (tablets) can be used in complex therapy with antiviral drugs, antimycotics, antiallergic drugs, bronchodilators, beta-agonists, hormone-containing drugs. In some cases, by taking the immunomodulator in question, it is possible to reduce the dose of one of the listed drugs taken together several times or to reduce the duration of therapy.
How often can I take Polyoxidonium?
When prescribing Polyoxidonium tablets, the dosage is selected taking into account several factors: the age of the patient, the type of disease, the severity and phase of the disease, individual characteristics body and related pathologies. Often, the remedy is used daily for 1-3 doses of 1-2 tablets (12 mg or 24 mg). There are schemes in which tablets are taken every other day or twice a week. Reception is made 20-30 minutes before the meal.
How long can I take Polyoxidonium?
Treatment regimens with the drug in tablet form provide for courses of continuous use lasting from 5 to 15 days. How much Polyoxidonium can be taken should be determined by the doctor who prescribes this medicine. If necessary, the course of treatment is repeated after three to four months, and the effectiveness of the application can be assessed using an immunogram.
Polyoxidonium - contraindications for use
Latin name
Latin name
Release form
Release form
Lyophilisate for solution for injection
Compound
Compound
- 1 vial contains:
- Active substance: polyoxidonium 3 mg;
- Excipients: mannitol, povidone, betacarotene - up to 4.5 mg.
Package
Package
5 bottles of 5 ml.
pharmachologic effect
pharmachologic effect
Immunomodulatory drug. Increases the body's resistance to local and generalized infections. The basis of the mechanism of the immunomodulatory action of Polyoxidonium is a direct effect on phagocytic cells and natural killers, as well as stimulation of antibody production.
Restores immune responses in secondary immunodeficiency states caused by various infections, injuries, burns, malignant neoplasms, complications after surgical operations, the use of chemotherapeutic agents, including cytostatics, steroid hormones.
Along with the immunomodulatory effect, Polyoxidonium has a pronounced detoxification activity, which is determined by the structure and high-molecular nature of the drug. Increases the resistance of cell membranes to the cytotoxic effect of drugs and chemicals, reduces their toxicity.
The use of Polyoxidonium in complex therapy can increase the effectiveness and reduce the duration of treatment, significantly reduce the need for antibiotics, bronchodilators, corticosteroids, and increase the period of remission.
The drug is well tolerated, does not have mitogenic, polyclonal activity, antigenic properties, does not have an allergenic, mutagenic, embryotoxic, teratogenic and carcinogenic effect.
Polyoxidonium for injection, indications for use
adults
:
- chronic recurrent inflammatory diseases of any etiology, not amenable to standard therapy, both in the acute stage and in remission;
- rheumatoid arthritis with long-term treatment with immunosuppressants;
- rheumatoid arthritis complicated by acute respiratory infections or acute respiratory viral infections;
- acute and chronic viral and bacterial infections (including urogenital infectious and inflammatory diseases);
- tuberculosis;
- acute and chronic allergic diseases (including pollinosis, bronchial asthma, atopic dermatitis) complicated by chronic recurrent bacterial and viral infection;
- during and after chemotherapy and radiation therapy of tumors;
- to reduce the nephro- and hepatotoxic effects of drugs;
- to activate regenerative processes (fractures, burns, trophic ulcers).
As monotherapy:
- for the prevention of postoperative infectious complications;
- for the correction of secondary immunodeficiencies arising from aging or exposure to adverse factors;
- for the prevention of influenza and acute respiratory infections.
Children aged 6 months and older
As part of complex therapy:
- acute and chronic infectious and inflammatory diseases (including ENT organs - sinusitis, rhinitis, adenoiditis, hypertrophy of the pharyngeal tonsil, SARS);
- acute allergic and toxic-allergic conditions;
- bronchial asthma complicated by chronic infections respiratory system;
- atopic dermatitis complicated by purulent infection;
- intestinal dysbacteriosis (in combination with specific therapy);
- rehabilitation of frequently and long-term ill children;
- prevention of influenza and acute respiratory infections.
Contraindications
Contraindications
- pregnancy (clinical experience is absent);
- individual hypersensitivity to the drug.
Carefully: acute renal failure, children under 6 months of age (clinical experience is limited).
Dosage and administration
Dosage and administration
adults
V / m or / in (drip)
For acute inflammatory diseases the drug is prescribed at a dose of 6 mg daily for 3 days, then every other day, the general course is 5-10 injections.
For chronic inflammatory diseases prescribed at a dose of 6 mg every other day, 5 injections are carried out, then 2 times a week, the course is at least 10 injections.
With tuberculosis appoint 6 mg 2 times a week, the course is 10-20 injections.
For rheumatoid arthritis appoint 6 mg every other day, carry out 5 injections, then 2 times a week, the course is at least 10 injections.
In acute and chronic urogenital diseases prescribe 6 mg every other day, the course is 10 injections in combination with chemotherapy drugs.
For chronic recurrent herpes- 6 mg every other day, course - 10 injections in combination with antiviral drugs, interferons and interferon synthesis inducers.
For the treatment of complicated forms of allergic diseases appoint 6 mg, the course is 5 injections: the first two injections daily, then every other day.
In acute allergic and toxic-allergic conditions the drug is administered intravenously at 6-12 mg in combination with antiallergic drugs (including clemastine).
During and after chemotherapy to reduce the immunosuppressive, hepato- and nephrotoxic effects of chemotherapeutic agents the drug is prescribed at a dose of 6-12 mg every other day, the course is at least 10 injections.
For the correction of immunodeficiency after chemotherapy and radiation therapy, after surgical removal of the tumor the drug is prescribed 6 mg 1-2 times a week, long-term use is indicated - from 2-3 months to 1 year.
For patients with acute renal failure, the drug is prescribed no more than 2 times a week.
Children
Methods of application are chosen by the doctor depending on the diagnosis, severity of the disease, age and body weight of the patient.
Parenterally (intramuscularly or intravenously drip) at a dose of 0.1-0.15 mg / kg daily, every other day or 2 times a week with a course of 5-10 injections (dose calculation is indicated in the table).
For intramuscular injection, the drug is dissolved in 1 ml of water for injection or 0.9% sodium chloride solution.
For intravenous drip injection, the drug is dissolved in 1.5-2 ml of a sterile 0.9% solution of sodium chloride, Polyglukin, Hemodez or 5% dextrose solution, sterilely transferred into a vial with the indicated solutions with a volume of 150-250 ml.
In acute inflammatory diseases: 0.1 mg / kg every other day with a course of 5-7 injections.
For chronic inflammatory diseases: 0.15 mg/kg 2 times a week for up to 10 injections.
In acute allergic and toxic-allergic conditions: intravenous drip at a dose of 0.15 mg / kg in combination with clemastine and other antiallergic drugs.
For the treatment of complicated forms of allergic diseases in combination with basic therapy: intramuscularly at 0.1 mg/kg in a course of 5 injections with an interval of 1-2 days.
Intranasally: daily at a daily dose of 0.15 mg/kg for 5-10 days.
Intranasally, the drug is administered 1-3 drops in one nasal passage after 2-3 hours (at least 3-4 times a day).
To prepare a solution for intranasal and sublingual use, a dose of 3 mg is dissolved in 1 ml (20 drops), a dose of 6 mg in 2 ml of distilled water, 0.9% sodium chloride solution or boiled water at room temperature. One drop of the prepared solution (50 µl) contains 0.15 mg of Polyoxidonium, which is prescribed per 1 kg of the child's body weight.
Side effects
Side effects
Local reactions: soreness at the injection site when administered intramuscularly.
special instructions
special instructions
In case of pain at the injection site, the drug is dissolved in 1 ml of a 0.25% procaine solution if the patient does not have an increased individual sensitivity to procaine.
The patient should be informed that the recommended dose and duration of treatment should not be exceeded without consulting a physician.
drug interaction
drug interaction
Polyoxidonium is compatible with antibiotics, antiviral, antifungal and antihistamines, bronchodilators, glucocorticosteroids, cytostatics.
Check other drug interactions with Polyoxidonium Injection
Storage conditions
Storage conditions
Store in a dry, dark place, out of the reach of children,
Lyophilisate for solution for injection and topical application at a temperature of 4° to 8°C.
Polyoxidonium for injections, instructions for use, download PDF
- Polyoxidonium por.d / in. 3mg n5
- Polyoxidonium Lyof. d / pr. r-ra d / in. and places. pr. 3mg fl. x5 b (r)
- Polyoxidonium bottles 3 mg, 5 ml, 5 pcs.
- Polyoxidonium lyophilisate for the preparation of a solution for injections 3 mg 5 ml bottles of 5 pcs.
- Polyoxidonium 0.003 n5 vial lyophile for solution
- Types and dosage
- Indications
- Tablets
- Lyophilisate
- special instructions
- Form of means - tablets
- Product form - lyophilisate
- Candles
- additional information
- Analogues and contraindications
- Side effects, compatibility and storage conditions
The drug Polyoxidonium is an effective and high-quality immune stimulant, the main purpose of which, based on the pharmacological action, is to raise the level of immunity. This drug greatly increases the degree of resistance of an adult, as well as a child's body to various infections, successfully copes with the consequences of immunodeficiency. The most effective common form of the drug is Polyoxidonium injections, which are intravenous as well as intramuscular injections. Other types of medication are also produced - these are candles and tablets.
General spectrum of action and secondary immunodeficiency
Polyoxidonium injections are a universal remedy for the elimination of complex secondary immunodeficiency. Due to this property, the drug is prescribed as an effective therapeutic drug in order to eliminate the recurrent consequences of advanced chronic diseases of the lungs, hearing organs, diseases of the urogenital tract, etc. In addition, the drug is prescribed for complex use as an active element in the treatment of a wide range of diseases: cancer, tuberculosis, allergies, intestinal dysbacteriosis, arthritis, ulcers.
With the help of injections of Polyoxidonium, it is possible to restore inhibited immune responses at the regenerative stage after injuries or burns, manifestations of malignant neoplasms, as well as the use of a chemotherapeutic technique. Injections of this remedy are indispensable for complications identified after a surgical operation. In fact, the drug effectively reduces the toxicity of the drugs and chemical components taken, further increasing the resistance of cells to the aggressive and destructive actions of various substances that destroy the structure of the cell membrane.
With the use of Polyoxidonium injections, prescribed as part of a whole therapeutic complex, the effectiveness of treatment is significantly increased, coupled with a reduction in its time. The need for the use of powerful antibiotics, glucocorticosteroids, drugs used to relieve bronchospasm practically disappears. The remission period is increasing.
Polyoxidonium is well tolerated by adults and children, does not stimulate the occurrence of allergic reactions, does not change the structure of DNA, and does not increase the risk of developing cancer. Can the medication be used by pregnant women? Yes, but only after professional advice. The drug clearly cannot be the cause of the mutation of the fetus or its abnormal development.
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Types and dosage
The following forms of Polyoxidonium are prescribed for use:
- rectal, as well as vaginal suppositories, or, in other words, suppositories, consisting of 6 and 12 mg of the substance;
- tablets containing exactly 12 mg of the active substance;
- powder to create a solution used exclusively in injections, drops (3 and 6 mg), - lyophilisate.
For more information about the dose of the drug, see the instructions for individual forms.
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Indications
In practice, the range of indications for the use of the device is quite extensive and multifaceted.
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Tablets
- treatment of complex chronic infections occurring in respiratory tract, hearing organs, oral cavity and sinuses;
- preventive processes of SARS, especially during the epidemiological period of influenza.
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Lyophilisate
- various long-term infectious diseases, often chronic;
- cancer prevention during different periods radiotherapy, chemotherapy;
- allergic reactions, especially bronchial asthma, dermatitis;
- prevention of tuberculosis, arthritis, herpes;
- damage to ligaments, bone tissue;
- receiving burns;
- prevention of secondary HIV infection.
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Candles (rectal, vaginal)
- various kinds of inflammatory diseases;
- sexual dysfunction;
- inflammation of the bladder;
- gynecological practice: leukoplakia, inflammation of the uterine mucosa, fallopian tube disease, vaginitis, cervical dysplasia;
- papillomas and other skin diseases;
- tumor therapy;
- infectious diseases, their prevention (different age range).
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special instructions
After the injection of the apparatus, there is a possibility of manifestation of soreness at the injection sites, especially after intramuscular injection. As for the question of an overdose of the device, it is simply impossible, based on the very nature of the drug.
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The form of the remedy is tablets
Instructions for use of the Polyoxidonium device in tablets:
- minor children from 12 years old - 1 pill, maximum 1-3 r / d (the dose directly depends on the severity of the disease);
- adults are recommended to consume up to 2 tablets, 1-3 r / d.
Take before meals, 45 minutes before. It is necessary to swallow the medication, not chewing, not resolving.
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The form of the product is lyophilizate
Instructions for using the drug in solution:
- intramuscular injections, intravenous drip: to prepare a solution, dilute 1.5 ml of powder from an ampoule with 3 ml of solution;
- the daily rate of injections is 6 mg. The method of therapy depends on the type of disease, its degree. During drip injection, the injection is made together with the solution, with a dosage of 200-400 ml. As a rule, a single course of treatment includes at least 10 appointments.
- Ratio: 100-150 mcg per kg of weight applicable to the age of 6 months.
The use of lyophilizate is contraindicated if:
- symptoms of an allergy to components;
- pregnancy, breastfeeding;
- acute kidney failure;
- the child is less than 6 months old.
