Okoferon eye drops: instructions and general information. Use of Okoferon during pregnancy. Composition and form of release.

Okoferon is a drug used in ophthalmology. Its main therapeutic activity is the regulation of local immune responses. Therefore, this drug is mainly used for the treatment viral diseases structures of the eyeball.

The main active ingredient of Okoferon is human recombinant interferon. It is he who has an immunomodulatory effect. One milliliter of eye drops contains approximately 200 thousand international units of this substance. In addition to interferon, this ophthalmic preparation also contains Excipients, which prevent the destruction of the main component and allow it to retain its therapeutic properties for a long time.

Eye drops must be prepared before use. To do this, take one bottle of powder and solvent, which are contained in the package. Everything is thoroughly mixed until completely dissolved, and only then instilled.

Mode of application

How to use Okoferon eye drops is as follows:

• mixing the lyophilizate with the solvent;
• put a special dropper on the bottle;
• a single dose is one drop (instilled in both eyes);
• the interval between instillations should be 2 hours, as the clinical manifestations the frequency of instillation of the drug decreases;
• the course of treatment is determined individually, on average it ranges from one to one and a half weeks.

Before starting treatment, contraindications are taken into account in order to prevent the development of serious complications. This process is carried out by an ophthalmologist. The main contraindications are:

• hypersensitivity to any component of the drug, which may develop in some patients;
• carefully prescribed during pregnancy and lactation.

Side effects

Against the background of treatment with this drug, one or another side effect can rarely be recorded. These include:

• allergic intolerance (swelling, rashes on);
• feeling foreign body after instillation;
• etc.

It should be noted that if at least one of the above symptoms appears, it is necessary to consult a doctor to decide on the possibility of further use of this remedy.

In the course of treatment with Okoferon, it is necessary to follow special instructions that will increase therapeutic efficacy and minimize the number and severity of side effects.

• it is necessary to observe a certain temperature during storage, which should be within 4-10º above 0º;
• an open vial can be stored for 4 weeks;
• the closed vial is stored for 2 years;
• if it is necessary to instill another drug, the interval should be 20-30 minutes.

For the treatment of eye diseases, you can find quite a few different medicines. They may differ in their method of application, composition, effectiveness, contraindications, and also in cost. You can find both very cheap drugs and very expensive ones.

To combat certain eye diseases, you can use drugs that contain a substance such as leukocyte interferon. These drugs are available in various types. You can find tablets, creams or ointments, powders for making a solution, as well as rectal suppositories.

In this article we will talk about the drops "Okoferon", which just belong to such drugs. Some provisions from the instructions for the use of this drug will be given, as well as what limitations and contraindications it has.

Characteristics of the drug

If you refer to the instructions that came with this drug, then according to the information indicated there, eye drops "Okoferon" refers to antiviral agents with immunomodulatory activity.

It also states that the composition of the drug contains human recombinant interferon- 2 million per milliliter. There is also an additional component. It is a solution of nipagin with a concentration of 0.1%.

The kit contains the components necessary for the preparation of the drug: liquid and powder for making drops. Before using the drug, you will definitely need to mix the available components. Each pack of Okoferon eye drops contains instructions for use, which you will need to read without fail.

Indications and restrictions for use

Before using any medication, you should definitely find out about those cases when it is not recommended to take it. We are talking about contraindications, which must be indicated in the instructions for use of each drug.

"Okoferon" can not be used by persons who experience hypersensitivity to the ingredients of the drug. The annotation to this tool states that there is no experience with the use of this drug by lactating and pregnant women. In such cases, if necessary, you should definitely consult a doctor.

Indications for the use of the drug are viral eye diseases. And also "Okoferon" can be used against herpes, localized on the organs of vision. At the same time, these eye drops can also be used as an additional drug in the treatment of certain eye diseases.

Instructions for use

Before using this drug, it will need to be prepared first. First, be sure to wash your hands. Then you need to open the two vials that come with the kit.

The liquid solution of nipagin must be introduced into the luophilized powder. Then you will need to wait until the mixed ingredients form a uniform consistency.

1. In the first days of therapy, the drug "Okoferon" is prescribed in the following dosage: two drops every two hours. The drug is injected into the conjunctival sac, in which the patient is assisted by a special pipette, which is located on the vial.
2. After the patient's condition improves, the dosage changes - further, you will need to inject one drop every two hours. The duration of therapy primarily depends on how severe the disease is, and can range from five to ten days.
3. In pediatrics, there are no specific rules for the dosage of the drug. Appointment is based on an individual approach to each patient. Instructions for the use of "Okoferon" does not contain provisions regarding dosage in relation to children.

Features of the use of eye drops Okoferon

Qualified specialists refer "Okoferon" to safe medicines. And also a lot of positive reviews relate to the high effectiveness of the drug in the fight against viral infections of the organs of vision.

Thanks to the active ingredient, increased resistance human body in the specified area. On the surface of viral cells there are receptors that bind recombinant interferon.

This causes inevitable changes in the viral structure, which does not allow them to further divide and multiply. Thus, an invisible protection is created that protects the organs of vision from re-infection.

If we turn to user reviews, it can be noted that for the most part they wear positive character. Many argue that the effect of using Okoferon eye drops becomes noticeable on the second day after the start of treatment.

The eyes become more resistant to new eye infections. As already mentioned above in the article, Okoferon drops can often be prescribed in conjunction with other drugs. This is also noted by users. The instructions state that such measures are allowed. However, it should be noted the need to take a half-hour break between the use of these funds.

"Okoferon" - analogues, price

In the event that it is not possible to purchase the desired drug, you can always try to find its analogue. Pharmacies very often have similar medicines that differ in name. You can specify the following analogues of "Okoferon":

The average price of eye drops "Okoferon" is 490 rubles. It may vary depending on the region where the patient lives. By the way, such a high price sometimes becomes the reason that people turn to the search for cheaper, but equally effective drugs.

Are various infections. Among them, herpes infection is considered one of the most dangerous.

This article characterizes Okoferon as an antiviral and immunomodulatory agent based on recombinant interferon alpha-2β. There are practical steps for preparing a solution for instillation into the eyes, recommendations for use are given.

Means specificity

Ocoferon are eye drops containing human recombinant (or genetically engineered) interferon alpha-2β. This form of interferon was obtained by microbiological synthesis in the twentieth century.

Its imperfection was that the interferon in the resulting solution retained its activity for a short time.

The solution to the problem of the short-lived activity of the drug was found when scientists introduced preservatives into the eye drops.

The new drug was named Okoferon. The preservatives in it retain their activity and the sum of the concentrations of dissolved particles in a freshly prepared medicine for two weeks.

Advantages of the drug

Okoferon is very effective in the complex treatment of viral keratitis. In patients who were prescribed this remedy as one of the antiviral drugs, the following changes in the state of the affected organ were noted:

• stabilization or disappearance of keratitis in a short time;
• reduction of redness, eye pain, tear secretion and fear of light already in the first stages of treatment;
• improvement of visual acuity;
• absence of allergic and toxic reactions.

Clinical studies have shown that the use of Okoferon in the complex therapy of herpetic eye diseases does not do any harm. The drug restores the corneal epithelium, dissolves inflammatory seals, improves vision, and reduces the duration of treatment.

Since the drug actively destroys the virus, it is prescribed for the prevention of ophthalmic herpes and in the treatment of cancer.

The effectiveness of treatment with the Okoferon medication depends on the early diagnosis of the disease, intensive complex treatment of viral keratitis under the guidance of an experienced ophthalmologist.

pharmachologic effect

A special form of interferon has immunomodulatory and antiviral activity. As an immunomodulator, Okoferon activates phagocytosis, that is, the process of capturing and absorbing viruses.

In addition, the drug stimulates the formation of antibodies - proteins of the blood plasma compound that prevent the reproduction of viruses or neutralize the toxins they secrete. The drug also stimulates the formation of biologically active substances of lymphokines - mediators of cellular immunity.

Recombinant interferon - alpha-2β affects specific membrane receptors, induces the synthesis of RNA, thereby the synthesis of proteins that prevent the reproduction and release of viruses. This is the antiviral effect of Okoferon.

Indications for use

Okoferon is a drug used in complex treatment various forms herpes eye:

• herpetic keratitis;
• keratoconjunctivitis;
• keratouveitis;
• retinitis;
• chorioretinitis;
• neurouveitis.

Release features, composition

Eye drops are available in the form of a powder, which is a white lyophilized porous mass. It comes with a solvent.

Each substance is in a transparent glass vial under sterile conditions. The set includes a polyethylene cap-dropper.

Ocoferon powder contains:

• the main active ingredient is recombinant interferon-alpha-2β (1,000,000 IU in one vial);
• additional fillers - sodium phosphate dodecahydrate, sodium dihydrophosphate dihydrate, sodium chloride, dextran -70.

Solvent for powder(5 ml in one bottle) consists of such components as:

• methyl parahydroxybenzoate (nipagin) (E 218) - 5 mg;
• water for injections.

Method of application and dosage

During treatment with Okoferon, it is necessary to conduct virological studies to determine the effectiveness of removing viruses from the blood.

Specific interferon is prescribed as an infusion in drops into the conjunctival sac. In order to start dripping, you need to prepare a solution of lyophisate and solvent. They are in different bottles of the same package of Okoferon.

The solution for instillation should be prepared as follows:

Every two hours, 1-2 drops of the drug should be instilled into the sore eye. The total number of instillations should not exceed 10 times a day. The course of treatment lasts from 7 to 10 days.

In the event of the disappearance of signs of the disease, the number of instillations can be reduced.

Interaction with other drugs

It is difficult to judge the results of the relationship of Okoferon with other ophthalmic forms, since this issue has not been studied enough. To avoid serious side effects, it is not recommended to use this remedy with narcotic, sedative and hypnotic drugs.

The patient's condition may worsen the combination of interferon with drugs that reduce the number of blood cells produced in the bone marrow.

Dangerous interaction of Okoferon with other drugs for the treatment of eye diseases will not occur if it is instilled for 30 minutes before or after installations with other ophthalmic drugs.

Overdose

Exceeding the amount of Okoferon while observing the dosing regimen is not possible.

Side effects

Eye drops based on specific interferon are usually well tolerated by patients. Very rarely allergic reactions occur.

At the beginning of treatment, strict control of the specialist over the reaction of the body is necessary. With the appearance of an allergy to the drug and other negative phenomena, the medicine should be discontinued.

Contraindications

Okoferon is not prescribed to patients with individual intolerance to the ingredients of the drug.

You can not prescribe a medication for severe forms of such diseases:

• alcoholism;
• addiction;
• cirrhosis of the liver;
• acute cardiac conditions;
• depression, diseases of the central nervous system;
• autoimmune diseases.

During pregnancy

Ocoferon was not administered to pregnant women. However, experience with alpha interferons proves the possibility of miscarriage. Therefore, the use of recombinant (or genetically engineered) interferon - alpha-2β in pregnant women is possible only in case of emergency.

When driving vehicles

You should not drive a car and operate moving mechanisms immediately after instillation of the medicine.

Terms and conditions of storage

Hermetically sealed vials with substances for the preparation of the solution must be stored in the refrigerator, on the top shelf, at a temperature of 4 ºС to 10 ºС. Relative Humidity should not exceed 60%. Avoid getting on medication sunlight. Keep away from animals and children.

Shelf life of components for the preparation of eye drops when stored according to requirements 2 years. Ready-to-use solution 14 days. The expired expiration date is a signal to dispose of the drug.

Vacation from pharmacies

The drug is on free sale.

• Average price in Russia - 636 rubles.
• Average cost in Ukraine - 117 UAH.

A drug Okoferon- an agent used in ophthalmology.
The drug exhibits immunomodulatory and antiviral activity.
Interferon alpha-2b interacts with the appropriate receptors on the cell surface. Thus, processes are activated that prevent the replication of viruses inside the cell, slow down cell proliferation. The immunomodulatory effect of interferon alpha-2b stimulates the phagocytic activity of macrophages, as well as the cytotoxic activity of T cells and natural killer cells.

Indications for use:
Drops Okoferon intended for use in the treatment of viral eye infections (herpetic infection).

Mode of application:
Before use Okoferon dissolved in 5 ml of solvent (0.1% solution of nipagin). 1 ml of the prepared solution contains 200,000 IU of recombinant human interferon alfa-2b.
The drug is instilled 2 drops into the conjunctival sac of the affected eye every 2 hours, but at least 6 times a day.
With a decrease in the symptoms of the disease, the volume of instillations can be reduced to 1 drop.
The course of treatment is 7-10 days.

Side effects:
In rare cases, local reactions are possible, including local allergic reactions, swelling and hyperemia of the eyelids, itching, flushing of the face, which disappear after discontinuation of the drug.

Contraindications:
It is contraindicated to use Okoferon with hypersensitivity to the components of the drug.

Pregnancy:
No experience with drops Okoferon during pregnancy or lactation.

Interaction with other drugs:
To avoid possible physico-chemical interaction Okoferon with other ophthalmic agents, it is advisable to use it 30 minutes before or 30 minutes after instillation of other drugs into the eyes.

Overdose:
Not observed.

Storage conditions:
Store in a dry place at 2 to 8°C.
Keep out of the reach of children. Shelf life after opening the vial - 28 days.

Release form:
Okoferon - eye drops, powder.
Package:
1000000 IU in a glass vial.
5 ml of solvent in a glass bottle.
A polyethylene dropper cap is added.

Compound:
1 vial of Okoferon contains interferon alpha-2b recombinant human 1000 000 IU.
Excipients: sodium phosphate dodecahydrate, sodium dihydrophosphate dihydrate, dextran-70, sodium chloride,
Solvent for Okoferon: 1 bottle of solvent (5 ml) contains methyl parahydroxybenzoate (nipagin) (E 218) - 5 mg, water for injection.

Additionally:
It is necessary to start treatment at the first manifestations of viral eye damage.
A drug Okoferon does not have a systemic effect. At viral infections Okoferon should be used in combination with recombinant human interferon alpha-2b preparations for systemic use (injections, suppositories).
The ability to influence the reaction rate when driving vehicles or operating other mechanisms
Since in rare cases local reactions are possible after taking the drug, you should not drive vehicles or work with mechanisms immediately after use.
Children. No experience with children.

Latin name: Ocoferon
ATX code: S01XA
Active substance: Interferon alfa-2b
Manufacturer: Biopharma, Ukraine
Pharmacy leave condition: Without recipe

Indications for use

It is used to combat viral diseases, in particular, for the treatment of those suffering from ophthalmodic.

Release form

The average price is 490 rubles.

It is released as a lyophilized powder in vials. Color - from light gray to milky. In addition to the instructions, the cardboard box with eye drops of okoferon contains a solvent for the powder, a dropper cap.

Compound

The powder vial contains human interferon recombinant alpha-2b. A ml of the prepared solution contains 200,000 IU.

Also in the box there is a solution for the preparation of the solution - 5 ml.

Medicinal properties

Okoferon has an antiviral and immunorestorative effect. The active component acts on the receptors, changes quickly occur inside the cells aimed at fighting the virus and healing the whole organism. It is excreted from the body with urine.

Interaction with drugs

If the ophthalmologist prescribes several drugs at the same time, instillations with Okoferon solution should be carried out together with other drugs with a difference of half an hour.

Application

To prepare a solution, the powder with the solvent should be mixed, then shaken a little to form a homogeneous mixture. Buried okoferon in the conjunctival sac. In this case, the lid of the dropper should not touch the mucous membrane with it.

In the course of treatment should be monitored, it is necessary to perform virological studies.

For adults, 2 drops of okoferon are enough, it is necessary to instill every 2 hours. As soon as improvement comes, the number of drops should be reduced to 1, applied at the same interval.

Application during pregnancy

During pregnancy, okoferon is prescribed in extreme cases.

Contraindications

Occasionally, patients have experienced allergies. In this case, it is necessary to cancel the use of the drug.

Overdose

At the indicated dosage, an overdose is unlikely.

Contraindications

Individual hypersensitivity to components.

Terms and conditions of storage

It is necessary to store the solution in a dry, dark place at a temperature not exceeding 4 ° - 10 ° C.

The prepared solution can be used for 28 days.

Analogues

Producer: Firn M Russia.

average price for the drug - 273 rubles.

Perfectly removes the symptoms caused by the virus, also good drug to combat allergic reactions, therefore it is used during the period of seasonal allergies.

Pros:

• Efficiency
• Acceptable price.

Minuses:

• Side effects.

The manufacturer is LENS-Pharm LLC, a subsidiary of Veropharm OJSC, Russia.

Price from 128 to 234 rubles, depending on the packaging.

Penetrating into the tissues of the eye, medicinal product acts on the immune system, slows down the reproduction of pathogenic microbes. Substances are rapidly excreted from the body. Available in the form of eye drops, it is also used in pediatric practice.

Pros:

• Efficiency
• Price.

Minuses:

• May cause allergies.