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International non-proprietary name
rimantadine
Pharmgroup
Antivirals
Compound
Active substance: rimantadine hydrochloride - 50 mg.
Excipients: lactose monohydrate (milk sugar) - 60 mg, potato starch - 37 mg, talc - 1.5 mg, calcium stearate monohydrate - 1.5 mg.
The drug has many contraindications. And also Rupafin. Analogues are accepted only after consultation with a doctor. Diazolin tablets are not allowed for people with stomach ulcers, diabetes, closed angle glaucoma, cardiac arrhythmias and epilepsy.
AT traditional medicine There are many ways to quickly get rid of allergy symptoms. They shouldn't have everything. But these prescriptions can be used as adjuvant therapy in combination with Rupafin tablets. treatment is much more effective. A popular recipe is based on a lens of water. Fresh plants pour hot boiled water and insist for several days. Up to half a liter of water requires 200 g of grass. With the finished paint, use a tablespoon three times a day.
pharmachologic effect
Rimantadine is active against various strains of the influenza A virus.
As a weak base, rimantadine acts by increasing the pH of endosomes, the membrane-bound vacuoles that surround viral particles after they enter the cell. Prevention of acidification in these vacuoles blocks the fusion of the viral envelope with the endosome membrane, thus preventing viral transmission. genetic material into the cytoplasm of the cell. Rimantadine also inhibits the release of viral particles from the cell, that is, it interrupts the transcription of the viral genome.
Good results also show calendula. If you wipe the hives, the allergic traces of the alcohol solution will go away quickly. Inside, you can take a tincture of calendula for water. 10 g of dried leaves pour 100 g of boiling water. Exit the medicine should be within 3 hours. Then the dye is taken several times a day.
Review of medicines "Drug Rupafina"
Shows really nice results in the treatment of allergies. Therefore, his opinions can be heard more positively. Experts note that the drug should be used to eliminate symptoms of lung allergies, such as hives or rhinitis. Tablets are not able to eliminate swelling or rashes. To this end, more radical means.
Pharmacokinetics
After oral administration, rimantadine is almost completely absorbed from the intestine. Absorption is slow. Communication with plasma proteins is about 40%. Distribution volume: adults - 17 - 25 l / kg, children - 289 liters. The concentration in nasal secretion is 50% higher than in plasma. The maximum concentration of the active substance in blood plasma at a dose of 100 mg once a day is 181 ng / ml, 100 mg 2 times a day is 416 ng / ml. Metabolized in the liver. Half-life - 24 - 36 hours; 75 - 85% of the dose taken is excreted by the kidneys mainly in the form of metabolites, 15% - unchanged.
Negative opinions are most often associated with the wrong medication. Patients report that headaches and excessive sleepiness may occur. When they forget that the drug is recommended not to be taken in combination with other drugs. Pleased with the cost of the drug "Rupafin". Prices for small packages do not exceed 250 rubles. You can save if you buy a big package. Its price in pharmacies is only 400 rubles.
response to a specific stimulus. For unpleasant symptoms to occur, you should try to avoid objects that cause the development of urticaria or rhinitis. If the allergy still exists, get Rupafin tablets. Price guide - all this can be indicated at the pharmacy, pharmacist. Use the medicine better for the appointment of a specialist.
In chronic renal failure, the half-life increases by 2 times. In persons with renal insufficiency and in the elderly, it may accumulate in toxic concentrations if the dose is not adjusted in proportion to the decrease in creatinine clearance.
Indications for use
Treatment and prevention of influenza in adults and children over 7 years of age.
Galenic form and amount of active ingredient per unit
Available without a prescription. In almost all pharmacies you can buy Rupafin drugs. Its price does not exceed 300 rubles. Professional information of the Swiss Compendium of Medicine®. Active ingredient: amantadini hydrochloride. Symptoms of Parkinson, Parkinson; drug-induced parkinsonism in adults.
Individual and collective prophylaxis in case of risk of infection Treatment of influenza at its onset in adults and children over 5 years of age. Conditions of treatment: any patient or group of patients taking Symmetrel should be subject to medical supervision.
Contraindications
- acute liver disease;
- acute and chronic kidney disease;
- thyrotoxicosis;
- hypersensitivity to rimantadine;
- pregnancy and period breastfeeding;
- children under 7 years old;
- with lactose deficiency, lactose intolerance, glucose-galactose malabsorption (since the drug contains lactose).
Use during pregnancy and during breastfeeding
Symmetrical capsules should be taken orally with food - preferably in the morning and afternoon - to prevent indigestion. These dosage recommendations are for patients with and without pretreatment. An initial low dosage is used to determine the individual response. The usual dosage can usually be obtained in 4-7 days. Exceptional dosage may provide greater relief but also increase toxicity, and the dose should be gradually increased at intervals of at least one week.
Rimantadine during pregnancy and breastfeeding is contraindicated.
Carefully
Arterial hypertension, cerebral atherosclerosis, liver failure, epilepsy, diseases of the gastrointestinal tract.
special instructions
When using rimantadine, exacerbation of chronic concomitant diseases is possible. Elderly patients with arterial hypertension have an increased risk of hemorrhagic stroke.
Amantadine works for a few days but often seems to lose some of its effectiveness after several months of continuous treatment. The effectiveness of amantadine can be prolonged by temporary arrest, which appears to restore its activity.
Combined treatment of Parkinson's syndrome
In patients on anti-Parkinsonian therapy, current treatment should be maintained initially, and in many cases the dose of other anti-Parkinsons can be gradually reduced without adversely affecting therapeutic outcome. Children from 10 years old, teenagers and adults up to 65 years old.
With indications of a history of epilepsy and ongoing anticonvulsant therapy against the background of the use of rimantadine, the risk of developing an epileptic seizure increases. In such cases, rimantadine is used at a dose of 100 mg per day simultaneously with anticonvulsant therapy.
Prophylactic administration is effective in contact with sick people, with the spread of infection in closed groups and with high risk disease during an influenza epidemic.
The emergence of drug-resistant viruses is possible.
Prophylaxis: Prophylactic treatment should be carried out in accordance with this schedule as soon as contact with an infectious agent has occurred; it should be continued throughout the influenza type A epidemic, usually for about 6 weeks. Treatment: It is recommended to start treatment for influenza as early as possible and continue for 4-5 days. When amantadine is taken within 48 hours of the onset of symptoms, fever and other effects subside within one day, and the inflammatory response of the bronchioles that usually accompanies influenza resolves more quickly.
Influence on the ability to drive vehicles and control mechanisms
During the period of treatment, it is necessary to refrain from driving vehicles and occupations by other potentially dangerous species activities that require increased concentration of attention and speed of psychomotor reactions.
Dosage and administration
Specific dosage instructions for all indications
Dosage and use in the elderly
Plasma concentrations of amantadine depend on renal function. Elderly patients tend to have a longer half-life and lower renal clearance than younger patients. In the presence of renal dysfunction, it is necessary to adjust the interval between doses.Patients with renal insufficiency
In patients with reduced renal function and in patients undergoing hemodialysis, the elimination half-life is significantly prolonged, which leads to an increase in the plasma concentration of amantadine. starting dose on the first day, dosage should be carefully adjusted by increasing dosage intervals depending on creatinine clearance.
Inside, after eating, drinking water.
Influenza treatment should begin within 24 to 48 hours of the onset of symptoms.
Adults on the first day are prescribed 100 mg 3 times a day; on the second and third days, 100 mg 2 times a day; on the fourth and fifth day, 100 mg once a day. On the first day of the disease, it is possible to use the drug once at a dose of 300 mg.
Dosage based on creatinine clearance
In patients treated for maintenance of Parkinson's disease in whom renal failure has recently been diagnosed, the initial dosage is not required, this can be immediately adjusted according to creatinine clearance. In patients on hemodialysis, the dosage is usually 100 mg per week, and if tolerance is good, this dose may be increased to 200 mg per week.
Ideally, plasma concentrations of amantadine should be monitored. Careful monitoring of the patient is recommended.
- Known hypersensitivity to amantadine or other ingredients of the product.
- A state of excitability and confusion.
- Refractory epilepsy, psychoses or delusional syndromes.
- Pregnancy.
Children aged 7 to 10 years are prescribed 50 mg 2 times a day; from 11 to 14 years - 50 mg 3 times a day.
Over 14 years old - doses for adults. Accepted within 5 days.
For the prevention of influenza, adults are prescribed 50 mg once a day for up to 30 days. Children over 7 years old - 50 mg once a day for 15 days.
Side effect
From the side digestive system: dry mouth, nausea, vomiting, loss of appetite, epigastric pain, flatulence.
These patients will be carefully monitored. The frequency of hallucinations, states of confusion and nightmares may be higher in the case of major mental disorders. Almost 50% of patients with Parkinson's disease have symptoms of depression and are therefore more likely to develop suicidal ideation with an intended effect. A number of suicide attempts, some of which are fatal, have been reported in patients treated with amantadine. Therefore, care should be taken to prescribe only the amount needed for effective treatment patient.
From the side of the central nervous system: headache, dizziness, insomnia, impaired concentration, drowsiness, anxiety, irritability, fatigue.
Other: hyperbilirubinemia, allergic reactions (skin rash, itching, urticaria).
Overdose
Symptoms: agitation, hallucinations, arrhythmia.
Remantadine indications for use
Particular attention should be given to patients with severe liver disease, myasthenia gravis, recurrent eczema, gastric ulcer, prostatic hyperplasia, or cardiovascular disease. In combination with anticholinergics or levodopa, contraindications to these substances should also be considered.
Peripheral edema may occur during treatment with Symmetrel, possibly due to local vascular disturbances. This should be considered in patients with heart failure. The dosage should be set with caution in patients with renal insufficiency because there is a risk of poisoning.
Treatment: gastric lavage, symptomatic therapy: measures to maintain vital functions. Rimantadine is partially excreted by hemodialysis.
Interaction with other drugs
Rimantadine reduces the effectiveness of antiepileptic drugs.
Paracetamol and ascorbic acid reduce the maximum plasma concentration of rimantadine by 11%.
Hypothermia has been observed in children, so when used as a prophylaxis for influenza, special care is required. Amantadine should not be given to children under 5 years of age. Because amantadine has anticholinergic effects and can cause mydriasis, it should not be administered to patients with untreated narrow-angle glaucoma.
Impaired impulse control
Patients should be monitored regularly to detect the development of impulse control disorders. The attention of patients and caregivers should be drawn to the possible appearance of behavioral symptoms with impaired impulse control, such as pathological dependence on gambling, increased libido, hypersexuality, spending and forced purchases, bulimic crises and compulsive drinking If such symptoms develop, dosage reduction or discontinuation of treatment should be considered.
Cimetidine reduces the clearance of rimantadine by 18%.
Adsorbents, astringents and enveloping agents reduce the absorption of rimantadine.
Alkaline urine agents (acetazolamide, sodium bicarbonate and others) increase the effectiveness of rimantadine due to a decrease in its excretion by the kidneys.
Release form
Tablets
Sudden amantadine may lead to worsening of Parkinson's symptoms or the appearance of symptoms similar to those of neuroleptic malignant syndrome, as well as catatonia or cognitive manifestations. Isolated reports indicate a possible association between exacerbation of neuroleptic malignant syndrome or neuroleptic induced catatonia and abrupt discontinuation of amantadine therapy in neuroleptic patients.
Therefore, treatment with amantadine should not be stopped abruptly. It is possible that transmission of resistant viruses is responsible for the failure of prevention in households and homes, but there is no evidence that infection with resistant virus would otherwise be with susceptible virus. Concomitant administration of amantadine with an anticholinergic, dopaminergic, or levodopa may increase confusion, hallucinations, nightmares, gastrointestinal disturbances, or other side effects atropine.
Storage conditions
In a dry place at a temperature not exceeding 25 ° C.
Best before date
Rimantadine is inexpensive antiviral agent. It is effective on early stages infection, in the later stages does not bring tangible results. See photo below.
Dosage form - tablets, capsules, syrup (for children).
Therapeutic effects of Remantadin
Single cases of psychotic decompensation have been reported in patients receiving amantadine at the same time as an antipsychotic or levodopa. Careful monitoring is recommended. The simultaneous administration of amantadine and a combination of diuretics reduces the clearance of amantadine, which leads to an increase in plasma concentration and may increase toxic effects.
Pregnancy and women of childbearing age
There are fetal risk indices based on experiments in humans and animals that have shown the risk to the fetus far outweighs the potential therapeutic benefit. Symmetrel is contraindicated in women who are or may become pregnant. Women of childbearing age should use highly effective contraceptive methods during treatment and then for 5 days after the last dose of amantadine.
Compound
The drug is produced by various manufacturers in the form of capsules, tablets, syrups (for children).
Each tablet contains 50 mg of the active ingredient - rimantadine hydrochloride. Auxiliary chemical components - lactose monohydrate, potato starch, stearic acid, aerosil, microcrystalline cellulose.
Rimantadine tablets from what they are, indications for use
The active component of the drug is a derivative of adamantane, which has antiviral action. The therapeutic effect is achieved due to the ability of rimantadine to block the entry and reproduction of the virus in the viral cells of the body. Because of this, the maximum effect of the drug is achieved at the initial stages of the penetration of the virus into the body, but is ineffective at the height of the disease.
The drug is used in the prevention and treatment of any strain of type A influenza virus (including swine flu), herpes, with influenza B has an antitoxic effect. With a cold, it is ineffective.
It is prescribed as a prophylactic for tick-borne encephalitis (for example, after a tick bite).
Analogues are cheap
Rimantadine is relatively inexpensive (compared to others), but it also has cheaper analogues.
Among these are:
- 1 "Rimantadit Aktitab"
- 2 "Rimantadin-Darnitsa", Kiev, Ukraine
- 3 "Remantadin"
- 4 "Rimantadine-sti"
- 5 "Remavir"
- 6 "Remantadin Aveksima"
- 7 "Amantadine"
- 8 Tamiflu (Oseltamivir)
- 9 "Zanamivir"
- 10 "Orvirem" (children's syrup).
All of these analogues are similar in pharmacological action, only the active substance, method of administration, and cost differ (although prices in Moscow, Odessa and Yekaterinburg for the same drug may also differ significantly).
What is the difference between rimantadine and rimantadine?
Both rimantadine and rimantadine are antiviral drugs used for influenza and SARS. The difference is that RIMANTADIN is the active substance and the more common name of the drug, while RIMANTADIN is the commercial name of the drug from one of the manufacturers. This is their main difference. That is, it is the same drug, named differently by its manufacturers, but identical in chemical composition.
Rimantadine tablets instructions for use for children
Before taking the drug, you should always consult with your doctor.
- 1 - 3 years - on the first day 30 ml, on the second and third - 20 ml, on the fourth and fifth - 10 ml;
- 3 - 7 years - the first day - 45 ml, the second and third days - 30 ml, the next two days - 15 ml;
- 7 - 14 years old - on the first day of admission - 60 ml, then two days 40 ml each, the next two days 20 ml each.
- up to a year - it is forbidden to accept.
Attention!
The dosage is calculated with the calculation of 1 teaspoon - 5 milliliters.
How to take rimantadine actitab tablets?
Reception in the form of capsules and tablets is allowed for adults and children over 7 years of age according to the following regimen:
- children aged 7 - 10 years - 100 milligrams daily for no more than 5 days;
- children aged 11-14 years - 150 mg daily for five days;
- everyone over 14 years old - on the first day of admission - 300 mg, the second and third - 200 mg, on the next two days of admission - 100 mg each.
It should be taken before meals, three times a day, dividing the dose into several times.
For colds in adults
With ARVI, taking rimantadine is not advisable, because it is not an antibiotic a wide range actions. For colds, amoxicillin and its derivatives will be more effective.
Dosage for prophylaxis
For preventive purposes, you can take one tablet for adults for no longer than 30 days, and for children, the most acceptable syrup with rimantadine is 2 (up to three years) or 3 (up to 7 years) teaspoons per day for 10-15 days, - for the purpose of prevention tick-borne encephalitis- only on the appointment of specialists, 2 tab. three days.
How much is prescribed during pregnancy?
During pregnancy, therapy with the use of rimantadine is prohibited. During lactation, the drug is placed in case of termination of breastfeeding.
Remantadin reviews for children
As to whether it is possible to give a child at the initial stage of these drugs, there is an ambiguous opinion. If something is written in a Wikipedia article, then it is automatically considered correct, even if the author of the article is not knowledgeable in this topic. Many trust opinions on forums, medical sites.
Nicholas: “Now there is such a huge amount of advertising for expensive drugs, but nothing has been heard about Remantadin for a long time. Although in my family it is always in the first aid kit in case of flu.
Victoria: “I have two children, at the onset of the disease I save them with rimantadine (although Komarovsky says that it is better to temper, play sports than feed them with medicine). I give syrup to the youngest, but the elder Dima is already drinking pills, although he complains that they are bitter.
Snezhana: “In the current conditions of economy, Rimantadine is just that. I always use it at the first symptoms of the flu, and I give it to my husband and children. It always helps, and no one has ever had side effects.
Tamara: “I heard that girls drink rimantadine for weight loss. Quite silly, because it's antiviral. If you drink more than the daily dose, then there is a risk of unwanted effects, and even poisoning.
Contraindications
The drug should not be taken by such groups of people:
- in the presence of sensitivity to rimantadine hydrochloride;
- with diseases of the liver and kidneys;
- with thyrotoxicosis;
- arterial hypertension;
- pregnant and lactating.
You should also exclude the simultaneous use of this medication with alcohol,
Side effects
In general, side effects are rare. Possible reactions of the digestive system: flatulence, nausea, vomiting, dry mouth, pain, anorexia.
Also, there may be reactions of the central nervous system to taking the drug: anxiety, headache, insomnia, irritability, drowsiness, fatigue, dizziness.
Also, in some cases, allergic reactions occur.
