Zhenale during periods of menstruation. Zhenale for abortion: use, reviews

If a young couple does not plan to have children in the near future, then they use contraception, fortunately, the range of them today is quite wide. In the arsenal of lovers there are condoms, spirals, patches and oral contraceptives - pills. But what if the unprotected event did take place? In an emergency situation, those created specifically for this will help.

When you need to act urgently

This kind of medication is used between 24 and 72 hours after sexual intercourse. Indications for the use of emergency pregnancy prevention methods are:

• unprotected sexual intercourse;
• condom rupture;
• problems with the intrauterine device;
• skipping 3 or more oral contraceptive tablets;
• rape;
• the very beginning of sexual activity.

One of the methods of force majeure contraception is the drug “Zhenale”. Instructions, reviews from doctors and buyers, as well as comparisons with similar medications are presented in our article.

Release form and description of the medication

This drug is produced in rather large round tablets, 1 piece in a package, tablet weight 10 mg, its color is light yellow, with a slight greenish tint. The above remedy should be taken orally two hours before meals or two hours after meals. The sooner a woman takes the drug after unprotected sexual intercourse, the faster and more effectively it will act. If vomiting occurs within 3 hours after taking the medicine, you should consult a doctor - this means that this particular medicine is not suitable for you, and you need to find a remedy with a similar effect as quickly as possible.

Contraindications and unwanted effects

Side effects are possible after taking Zhenale. They depend on personal intolerance to the components of the drug. This may include nausea, vomiting or headache. There is no need to worry about this, since such symptoms are possible after using any medicine. Discharge after “Zhenale” is also possible, it can be bloody or colorless, this is a variant of the norm. Like any medicine, postcoital contraceptives have contraindications. These include kidney failure, low hemoglobin, pregnancy and lactation.

Please note that emergency contraception "Zhenale" does not protect against sexually transmitted diseases and AIDS; its effect is only aimed at preventing unplanned pregnancy. The above-mentioned drug cannot be used instead of regular contraception or after each individual sexual intercourse. It is not suitable for daily use as it is designed for emergencies. For permanent contraception, it is necessary to select regular oral contraceptives, which are taken orally every day at the same time.

The use of the Zhenale contraceptive is required only in the absence of pregnancy, since it does not cause abortion and will not get rid of an existing pregnancy, but it may well cause harm to the fetus. If, after taking the above-mentioned drug, fertilization does occur, medical or surgical termination of pregnancy is recommended. If a woman decides to keep the child, the risk of pathologies in the development of the unborn baby cannot be excluded.

The influence of "Zhenale" on women's health

This drug is a non-hormonal drug, so it does not affect a woman’s hormonal levels and does not disrupt the menstrual cycle. Menstruation after “Zhenale” comes on time, if the cycle is already established, the above-mentioned remedy does not cause any unpleasant sensations. While taking medications, drinking alcoholic beverages in large doses is prohibited. Of course, we cannot say that Genale and alcohol are categorically incompatible. Alcohol does not affect the effectiveness of this postcoital contraceptive, but you should still not combine the drug with it. The medicine discussed in the article has gained a good reputation among consumers - read about this below.

"Zhenale" - review and opinions about the drug

Women who have tried this means of express contraception note its high efficiency and lack of harm to the body, since it does not contain a lethal dose of hormones, but only one antihormone, which blocks the activity of sperm and prevents pregnancy. After taking Zhenale, many women were pleasantly surprised by the absence of unpleasant, and even painful, sensations after taking the pill. Many emergency contraceptives are difficult to tolerate by the body and cause a lot of inconvenience and side effects. After taking this drug there were no such troubles.

Consumers speak well of Zhenal also because it is not in short supply and can be easily purchased at almost any pharmacy. A doctor's prescription is not required for this, although it is advisable to consult a gynecologist before using it. This product costs about 300 rubles. An undoubted advantage is that periods after “Zhenale” come on time, at most they can be delayed for a couple of days, but this happens quite rarely. This means that the cycle does not break down, which cannot but please customers. Particularly thrifty consumers keep this product in their home medicine cabinet “just in case.”

Girls who have experienced the effects of the drug “Zhenale” usually leave positive reviews. Many people are surprised how gently it acts and does not affect weight. But before taking the pill, it is advisable to do a pregnancy test, since those who have regular sexual intercourse could “accidentally” become pregnant earlier, and in this case the drug will cause great harm to the fetus. This information is for those who still decide to keep the child.

Pregnancy and "Genale"

Those who are planning a pregnancy in the near future need to wait 2-3 weeks after “Zhenale” and then begin active actions. During the specified time, the drug is completely eliminated from the body and the health of the mother and the unborn baby is no longer threatened. This product has passed all clinical trials. And although the instructions indicate possible side effects and discomfort, in fact, a very small percentage of women feel unwell after taking the pill. Doctors also recommend “Zhenale” in emergency cases: the reviews of gynecologists about it inspire confidence. Doctors note that this product was created taking into account the characteristics of the female body, it does not disrupt the hormonal levels of patients.

A very important fact is that menstruation after “Zhenale” begins on time, according to the usual schedule. Naturally, the above-mentioned drug cannot be abused; it is recommended only in emergency cases, in particular, after unprotected sexual intercourse. The main component of "Zhenale" is mifepristone (of course, not only it, but in combination with other ingredients). It is usually used when necessary, and in doses much larger than one tablet. But to protect against unwanted pregnancy, 10 mg of the drug is quite enough.

It has already been mentioned that the delay after “Zhenale” is an extremely rare phenomenon, a maximum of a couple of days, and after this time the cycle is established. Gynecologists unanimously declare that the above-mentioned emergency contraception is the most effective. It was invented recently, therefore it includes all the latest developments in pharmacology and medicine. The effectiveness of Zhenale has been clinically proven, and women who have used this remedy claim that it is the best among similar medications.

Drugs with similar effects

Since “Zhenale” was created quite recently, it is worth mentioning the post-coital means that girls used before the above-mentioned contraceptive appeared on the market. Previously, medications such as Escapelle, Postinor or Gynepristone were used to protect against unwanted pregnancy. Let's look at them in more detail and compare the effectiveness of these funds with Zhenale.

Until recently, “Escapel” was the latest development of scientists in the field of express contraception, and was used when conventional methods of protection against unwanted pregnancy were not suitable or failed. The main component of the drug, levonorgestrel, is also used in Postinor. The advantage of this medicine and its main difference from its analogues is that it can be used even during breastfeeding, which means that it also acts gently and gently, like Zhenale. If pregnancy has already occurred, then “Escapelle” will not harm the fetus, that is, the baby will be born healthy. The effectiveness of this drug is as high as the previous one: all women who used this remedy avoided pregnancy.

Among the side effects of Escapelle, the most frequently mentioned are disruptions and disturbances of the menstrual cycle, heavy discharge, pain in the lower abdomen, and with them nausea and migraines. Few people have experienced any discomfort when taking this drug. Women also mentioned an allergic reaction to this medicine - redness and rashes on the skin, nausea, general weakness of the body, upset stomach, lethargy and drowsiness. But almost all customers were satisfied with the effect of the product, since it perfectly protected against the consequences of unprotected sexual intercourse. Russian scientists and gynecologists confirm the effectiveness of the drug, it is 97%. But do not forget that the product does not protect against sexually transmitted infections.

How the drug "Escapelle" works, dosage, indications and contraindications for use

The principle of operation of Escapelle is that it slows down the ovulation process and prevents the egg from leaving the ovary for fertilization. And if this has already happened, then this remedy prevents the fertilized egg from entering the uterus. The main condition is to take the pill no later than three days after sexual intercourse. If pregnancy occurs earlier, everything is meaningless. It is not recommended to take this drug constantly, since a large amount of hormones will harm the body, increase the number of side effects and reduce the activity of its action. There are no age restrictions for using Escapelle; you can take it from the beginning of sexual activity, but before that it is recommended to consult a gynecologist. In addition, to purchase the drug you need a doctor's prescription. This medicine is also available in 1 tablet per package. Contraindications to the use of "Escapel" may be:

• intolerance to the components of the drug;
• liver or kidney failure;
• pregnancy.

Very often, taking the pill is accompanied by discharge and bleeding from the genital tract, you should not be afraid of this, this is the norm. It is also advisable to take a pregnancy test before taking the medicine. This contraceptive is taken orally and should be taken with a sufficient amount of water. If vomiting begins within two to three hours after taking it, it is recommended to take another tablet to enhance the effect. And before the onset of the next menstruation, it is necessary to use local contraceptive methods, for example, a condom, since frequent use of the above-mentioned medicine increases the amount of discharge.

Comparison of the drugs discussed in the article

Since both “Zhenale” and “Escapelle” are similar express contraceptives, each woman herself or after consulting with a doctor must decide which method she will take. Another representative of the line of contraceptive drugs is Postinor. It has been known for a long time and has been sold for several decades, until recently being practically the only remedy that protected against unwanted pregnancy after unprotected sexual intercourse. The effectiveness of Postinor is only 85%, previously this was enough, but in comparison with previous means of emergency contraception, it is clear that it is inferior to its analogues. Modern similar drugs are more effective. "Postinor" is produced in a package of 2 tablets. Like the above medications, it must be taken orally, one tablet in the first 72 hours after intimacy, and the second after 12 hours after consuming the first.

The sooner a woman takes the drug after unprotected sex, the greater its effectiveness. The Postinora tablet contains a large concentration of hormones, so taking such a contraceptive is a kind of stress for the female body. Just like similar medications, you should not take Postinor too often, and after use you must use barrier contraception.

A large amount of hormones (with frequent use of the medicine) can weaken the body and disrupt the menstrual cycle. An allergic reaction in the form of a rash, as well as swelling, nausea and vomiting, pain in the lower abdomen, fatigue and lethargy, is possible to the above-mentioned contraceptive. Many women noted a sharp deterioration in their health and general condition after taking the pills. The effect of this medication is accompanied by heavy bleeding from the genitals. After taking Postinor, it is recommended to consult a gynecologist and carefully follow his recommendations.

Since Postinor is an analogue of Zhenale, the actions of both drugs are approximately similar, they pursue the same goal, but achieve it in different ways. Women who, due to circumstances, were forced to use emergency contraceptives, when choosing drugs (“Zhenale” or “Postinor”), preferred the first one. Almost all customers note that “Zhenale” acts more gently, does not cause painful or unpleasant sensations, and most importantly, does not disrupt the menstrual cycle. And after “Postinor”, ​​menstruation comes either earlier or later than the due date, and is accompanied by pain in the lower abdomen and heavy discharge. Most customers complain of a sharp deterioration in their health after taking Postinor.

It is worth noting that the prices for these contraceptives are approximately the same. When choosing, it is worth considering that an unplanned pregnancy after Zhenale can occur with a very low probability, and it is much easier to tolerate.

Other emergency contraceptives

When talking about postcoital methods of preventing pregnancy, one cannot fail to mention the drug Ginepristone. Recommendations for the use of this medication, as well as the three previous ones, are the need for emergency contraception if there has been sexual intercourse without protection or a condom has failed. The essence of its action is that, due to the high concentration of hormones, the drug blocks ovulation and prevents sperm from fertilizing the egg. It also has contraindications, they are:

• renal failure;
• bronchial asthma;
• lung diseases;
• heart failure;
• pregnancy;
• lactation.

This drug, just like Escapelle and Postinor, has unpleasant side effects, including discomfort in the lower abdomen, nausea, vomiting, upset stomach, dizziness, allergies and skin rashes, weakness and drowsiness, as well as menstrual irregularities, abundant scarlet discharge from the genital tract.

Almost all emergency contraceptives have the same method of use, be it Zhenale or Gynepristone. The latter must be consumed orally no later than 72 hours after unprotected sexual intercourse. It is recommended to take the tablet with water and then not eat for two hours. This medicine is produced in 1 tablet per package, the drug costs 200-250 rubles. Dispensed with a doctor's prescription. Just like about the drug “Zhenale”, consumer reviews of “Ginepristone” are positive, but still the side effects and discomfort from the last means of contraception persuade women to choose “Zhenale”.

How to make the final choice

From our article you learned everything about the drug “Zhenale”: reviews from doctors and consumers about it, indications for use - and also received clear data comparing this means of post-coital contraception with other similar medications. Based on a detailed description of four similar drugs, we can conclude that of all the above contraceptives, Zhenale is the undoubted leader.

It has more advantages: no pain or discomfort after taking the pill, no heavy discharge, which also brings a lot of inconvenience. Although, in principle, all four contraceptives cope well with the task: the effectiveness of Postinor is 85%, Escapel is 97%, Ginepristone is also 97%, and the effectiveness of Zhenale is as much as 99%. And if science knows cases where, after taking the Postinor pill, a woman still became pregnant, then after using Zhenale, the likelihood of such surprises is practically reduced to zero.

Which of the above-mentioned drugs to choose is determined by each woman herself. This depends on personal tolerance to the components of the drug, on the health and age of the patient, and on the advice of the gynecologist. The main thing is that before taking emergency contraceptives, you need to consult with your doctor, since each of these drugs is a powerful drug, and taking one pill is still stressful for the body. Before and after using such a medicine, a woman is advised to listen to her own feelings and observe how she is feeling, paying attention to possible changes.

We hope our article will help you make a choice between the drugs “Escapelle” or “Zhenale”, as well as other similar ones. And finally: it is better to avoid unprotected sexual intercourse, use condoms or other barriers, and do not miss taking oral contraceptives on time, then you simply will not need post-coital contraception.

Excipients: lactose monohydrate - 123.4 mg, potato starch - 22 mg, K25 - 6 mg, sodium carboxymethyl starch - 5 mg, magnesium stearate - 1.6 mg.

1 PC. - contour cellular packaging (1) - cardboard packs.
1 PC. - contour cell packaging (2) - cardboard packs.
1 PC. - orange glass jars (1) - cardboard packs.
2 pcs. - orange glass jars (1) - cardboard packs.

pharmachologic effect

Synthetic steroidal antiprogestogen drug. It blocks the action at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.

Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

Pharmacokinetics

Suction and distribution

After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In the blood, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.

Removal

After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T 1/2 is 18 hours.

Indications

- emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).

Contraindications

- acute or chronic renal and/or liver failure;

- long-term therapy with glucocorticosteroids;

- porphyria;

- anemia;

- hemostasis disorders (including previous treatment);

- presence of severe extragenital pathology;

- adrenal insufficiency;

- pregnancy;

- lactation period;

- a history of hypersensitivity to mifepristone and/or auxiliary components.

Dosage

You should take 1 tablet. orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.

Side effects

From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.

From the digestive system: nausea, vomiting, diarrhea.

From the side of the central nervous system:, dizziness.

Others: weakness, hyperthermia, urticaria.

Overdose

In cases of drug overdose, adrenal insufficiency may occur.

Drug interactions

The use of NSAIDs should be avoided for 8-12 days after taking the drug.

special instructions

The drug does not protect against sexually transmitted diseases and AIDS.

After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.

A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.

Synthetic steroidal antiprogestogen drug. It blocks the action of progesterone at the receptor level and does not have gestagenic activity. Antagonism with GCS due to competition at the level of communication with receptors was noted.

Depending on the phase of the menstrual cycle, it causes an increase in the contractility of the myometrium, stimulating the release of interleukin-8 in choriodecidual cells, increasing the sensitivity of the myometrium to prostaglandins. As a result of the action of the drug, desquamation of the decidua occurs and the fertilized egg is expelled. Causes inhibition of ovulation, changes in the endometrium and prevents the implantation of a fertilized egg.

Pharmacokinetics

Suction and distribution

After a single oral dose, Cmax is reached after 1.3 hours. Absolute bioavailability is 69%. In blood plasma, mifepristone is 98% bound to proteins: albumin and acidic α1-glycoprotein.

Removal

After the distribution phase, excretion occurs slowly at first, the concentration decreases by half between 12-72 hours, then more quickly. T 1/2 is 18 hours.

Release form

The tablets are light yellow with a greenish tint, round, biconvex.

Excipients: lactose monohydrate - 123.4 mg, potato starch - 22 mg, povidone K25 - 6 mg, sodium carboxymethyl starch - 5 mg, magnesium stearate - 1.6 mg.

1 PC. - contour cellular packaging (1) - cardboard packs.
1 PC. - contour cell packaging (2) - cardboard packs.
1 PC. - orange glass jars (1) - cardboard packs.
2 pcs. - orange glass jars (1) - cardboard packs.

Dosage

You should take 1 tablet. orally 2 hours before or 2 hours after a meal (in the next 72 hours after unprotected sexual intercourse), regardless of the phase of the menstrual cycle.

Overdose

In cases of drug overdose, adrenal insufficiency may occur.

Interaction

The use of NSAIDs should be avoided for 8-12 days after taking the drug.

Side effects

From the reproductive system: bloody discharge from the genital tract, discomfort and pain in the lower abdomen, exacerbation of inflammatory diseases of the uterus and appendages.

From the digestive system: nausea, vomiting, diarrhea.

From the side of the central nervous system: headache, dizziness.

Other: weakness, hyperthermia, urticaria.

Indications

• emergency (postcoital) contraception within 72 hours after sexual intercourse without previous use of contraceptives or methods, as well as in case of unsuccessful use (including an error when using the calendar method, unsuccessful interruption of sexual intercourse, rupture or slipping of the condom).

Contraindications

• acute or chronic renal and/or liver failure;
• long-term therapy with glucocorticosteroids;
• porphyria;
• anemia;
• hemostasis disorders (including previous treatment with anticoagulants);
• the presence of severe extragenital pathology;
• adrenal insufficiency;
• pregnancy;
• lactation period;
• a history of hypersensitivity to mifepristone and/or auxiliary components.

Features of application

Use during pregnancy and breastfeeding

The drug should not be used during pregnancy. Breastfeeding should be stopped for 14 days after taking the drug.

Use for liver dysfunction

Use for renal impairment

Use in elderly patients

special instructions

The drug does not protect against sexually transmitted diseases and AIDS.

After use as postcoital contraception and until the end of the current menstrual cycle, subsequent sexual intercourse without the use of contraceptives is not recommended. For further sexual intercourse, a barrier method of contraception should be used.

A 10 mg dose of the drug is not sufficient to cause abortion, so before further use, a highly sensitive pregnancy test should be performed to ensure that this drug is used only in the absence of pregnancy. If pregnancy occurs despite the use of the drug, it is recommended to terminate it with medication or surgery. If the patient decides to continue the pregnancy, it is impossible to completely eliminate the risk to the health of the unborn child.

Impact on the ability to drive vehicles and operate machinery

The effect of the drug on the ability to drive a car and operate machinery has not been noted.

Zhenale is an antigestagenic drug for internal use. Its chemical formula is dominated by the synthetic antiprogestogen steroid mifepristone, which blocks the action of the hormone progesterone at the receptor level, while not having gestagenic activity.

Under the influence of the Zhenale tablet, the fertilized egg is removed, which entails a change in the endometrium, a noticeable inhibition of ovulation and an obstacle to the implantation of a fertilized egg.

The maximum concentration in plasma is noticeable after approximately one hour, and the half-life is 18 hours.

Excipients include lactose monohydrate, potato starch, povidone, sodium carboxymethyl starch and magnesium stearate.

Zhenale is produced in the form of round tablets of yellow color with a green tint.

Among analogues, Postinor is known.

Indications and contraindications for the use of Zhenale

The use of Zhenale is appropriate if emergency contraception is needed after unprotected or unplanned sexual intercourse, but not later than 72 hours.

The list of contraindications is quite comprehensive, so it is better to read the instructions before using the tablets. Thus, taking Zhenale is not indicated for pathologies of the kidneys and liver, porphyria, anemia, adrenal insufficiency, pregnancy, lactation, as well as for long-term therapy with glucocorticosteroids. Restrictions also apply to patients who experience hypersensitivity to the components of this contraceptive.

Side effects and overdose of Zhenale

Side effects after using Zhenale can affect many vital systems. Thus, in the reproductive system, blood discharge from the vagina, discomfort and pain in the lower abdomen, as well as exacerbation of pathological processes in the appendages and uterus are possible. Digestive upset is accompanied by nausea, vomiting and diarrhea, and central nervous system disorders are represented by dizziness and migraine attacks. In addition, in some clinical pictures there are allergic reactions on the skin, in particular, urticaria, itching and swelling.

In cases of Zhenale overdose, adrenal insufficiency may predominate.

Instructions for use Zhenale

The drug is taken orally. One Zhenale tablet orally two hours before or two hours after your usual meal, but no later than 72 hours after sex.

Features of the use of Zhenale tablets

Taking the drug does not depend on the menstrual cycle.

Zhenale does not protect against sexually transmitted diseases and AIDS.

This contraceptive is not a method of permanent contraception, and should be taken only in emergency cases. Do not take monthly or several times during one menstrual cycle.

In the future, choose a more reliable means of contraception for regular use.

If Zhenale tablets are ineffective and pregnancy occurs, it must be terminated surgically or medically. If you want to continue the pregnancy, the risk of pathological development of the fetus increases, and the child will be born with serious pathologies.

Zhenale's influence on driving vehicles and other mechanisms is not observed.

Store in a cool place and use as directed.

Drug interactions. Do not use NSAIDs for 8-12 days after taking Zhenale, but otherwise there are no restrictions.

Reviews about the drug Zhenale, price

Of course, many patients prefer the decades-tested medical drug Postinor as emergency contraception, but the popularity of Zhenale is also growing every day.

The fact that Zhenale contains only one tablet, which protects against pregnancy, is captivating, while taking Postinor includes two pills, which should be taken according to a certain scheme. There is only one conclusion: Zhenale is easy to use.

Reviews about Zhenal are extremely positive, since the drug is a real lifesaver after thoughtless sexual intercourse. It gives a 99% guarantee that pregnancy will not occur in the future.

There are no negative reviews regarding the uselessness of Zhenale. It is extremely rare to find notes about the detection of side effects that are limited exclusively to nausea and dizziness.

The use of Zhenale does not require consultation with a specialist, but it still does not hurt to read the instructions carefully before taking it. The drug is truly highly effective, so many women use it with confidence.

Price for Zhenale 10 mg tablet x1 - 305 rubles

01:31 Zhenale: instructions, application, reviews -

Unprotected sexual intercourse often leads to an extremely unwanted pregnancy, which is not included in the plans of many women. That is why many ladies know firsthand about Zhenale tablets, which provide emergency contraception. General description of Zhenale tablets Zhenale is an antigestagenic drug for internal use. Its chemical formula is dominated by the steroidal antiprogestagen agent of synthetic origin mifepristone, which blocks the [...]

Zhenale belongs to the group of means for emergency contraception. The active ingredient is mifepristone of synthetic origin in the amount of 10 mg per tablet.

The drug has an antigestagenic effect, which is aimed at blocking the action of progesterone at the receptor level. Take 1 tablet once 2 hours before or after meals, but no later than 3 days after sexual intercourse.

Helps reduce the number of abortions. It is used in the following cases:

• damage or incorrect use of barrier methods of contraception;
• skipping pills when taking oral contraceptives;
• spontaneous prolapse of the intrauterine device;
• unprotected sexual intercourse;
• in women who have rare sexual intercourse;
• rape.

Zhenale should be used only as prescribed by a doctor, as these tablets have contraindications:

• renal, adrenal or liver failure;
• anemia and other extragenital pathology of severe severity;
• long-term use of glucocorticosteroids and anticoagulants;
• hypersensitivity to the drug;
• pregnancy and lactation (and after taking the drug you must stop breastfeeding for two weeks);
• after completion of therapy, do not take drugs from the group of non-steroidal anti-inflammatory drugs for 1-1.5 weeks.

The influence of Zhenale on the menstrual cycle

Mifepristone causes various hormonal disorders in the body; which ones exactly depends on the dosage. A distinctive feature of the drug is the possibility of its use in different phases of the menstrual cycle.

In the first phase of the cycle, Genale slows down the maturation of the dominant follicle, as a result of which the onset of ovulation shifts by 3-4 days. Due to inhibition of ovulation after taking Zhenale, menstruation is delayed.

Zhenale, taken in the next phase, leads to secretory changes in the endometrium, which do not allow the fertilized egg to penetrate the uterine mucosa.

The use of mifepristone during pregnancy at a dosage of 200 mg or more stimulates the synthesis of prostaglandins in the endometrium, promotes contraction of the muscular layer of the uterus, detachment and removal of the fertilized egg. This allows it to be used in combination with other drugs for medical abortion in the early stages, and later for artificial induction of labor.

The use of mifepristone at any dosage may cause the following adverse reactions:

• bloody discharge from the genital tract up to uterine bleeding, which is rare;
• pain in the lower abdomen;
• exacerbation of inflammatory diseases of the pelvic organs;
• general weakness, headache, dizziness; increased body temperature;
• nausea, vomiting, diarrhea;
• skin rashes.

When does your period start after taking Zhenale?

The most effective methods of preventing pregnancy are the introduction of an intrauterine device and hormonal drugs:

• gestagens (levonorgestrel);
• estrogen-gestagen drugs (combined oral contraceptives);
• antiprogestins (mifepristone).

When considering commonly used drugs, their positive and negative sides, and data from international studies, we can say that antigestagens are the most effective and gentle drugs compared to gestagens or COCs.

The first periods after taking Zhenale may be scanty. They usually appear on time or with a delay of several days. During the first months, disturbances in the menstrual cycle are possible, but gradually the cycle is restored.

Lack of menstruation after taking Zhenale

If the pregnancy test is negative, and your period does not appear after taking Zhenale, then you should not worry ahead of time. In the first few days this is an adverse reaction to the medicine.

But a delay can also indicate pregnancy, even if the test shows nothing. A false negative result may be due to low levels of human chorionic gonadotropin in the urine. To rule out conception for sure, it is better to determine - this analysis is able to recognize pregnancy in the first days of the delay.

When taking Zhenale, pay attention to the following:

• Genale does not protect against sexually transmitted diseases and AIDS;
• after using the drug, be sure to use reliable methods of contraception;
• If there is a hormonal imbalance or delay, you should not try to induce menstruation with the help of Zhenale. See a doctor and get tested to determine the cause;
• the dose of the drug is too small to terminate a pregnancy, so before use you need to be sure that you are not pregnant;
• If pregnancy occurs while taking mifepristone, termination by medication or surgery is recommended (vacuum aspiration is preferable). If a woman wishes to continue her pregnancy, the risk of developing congenital anomalies of the fetus cannot be excluded;
• do not take the drug on a regular basis as a contraceptive - This is a one-time contraception!

Vladlena Razmeritsa, obstetrician-gynecologist, especially for the site

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